75974-6

KRAS gene targeted mutation analysis in Blood or Tissue by Molecular genetics method

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Part Description

LP19732-4 KRAS gene
The KRAS gene (Kirsten rat sarcoma viral oncogene homolog) [HGNC Gene ID:6407] is located on chromosome 12p12.1. This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008] [NCBI Gene ID:3845] Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component: KRAS gene targeted mutation analysis
Property: Find
Time: Pt
System: Bld/Tiss
Scale: Doc
Method: Molgen

Additional Names

Long Common Name: KRAS gene targeted mutation analysis in Blood or Tissue by Molecular genetics method
Short Name: KRAS gene Mut Anl Bld/T
Display Name: KRAS gene targeted mutation analysis Molgen Doc (Bld/Tiss)
Consumer Name Alpha Get Info: KRAS gene targeted mutation analysis, Blood or tissue specimen

Basic Attributes

Class: MOLPATH.MUT
Type: Laboratory
First Released: Version 2.50
Last Updated: Version 2.73 (MIN)
Change Reason: Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.; Based on LOINC Committee review (June 2019), updated the Property from "Prid" to "Find" and Scale from "Nar" to "Doc" to align with the current LOINC model for naming collections of information reported in narrative and/or structured formats.
Order vs. Observation: Both
Common Test Rank Get Info: 16743

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	Γονίδιο KRAS στοχευμένη ανάλυση μεταλλάξεων:Εύρεση:Pt:Αίμα/Ιστός:Doc:Μοριακή γενετική Synonyms: Γονίδιο Γονίδιο KRAS Εύρεση
es-ES	Spanish (Spain)	Gen KRAS Analisis de mutaciones:Hallazgo:Punto temporal:Sangre o tejido:Doc:Genética molecular
es-MX	Spanish (Mexico)	Análisis de mutaciones dirigidas al gen KRAS:Hallazgo:Punto temporal:Sangre o tejido:Documento:Genética molecular
fr-FR	French (France)	KRAS gène mutation cible trouvée:Recherche:Ponctuel:Sang/Tissu:Document:Biologie moléculaire
it-IT	Italian (Italy)	KRAS, gene analisi di mutazione mirata:Osservazione:Pt:Sangue/Tess:Doc:Molgen Synonyms: Gene KRAS Genetica molecolare Mutazione genica Osservazione Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL	Dutch (Netherlands)	KRAS-gen doelgerichte mutatie-analyse:bevinding:moment:bloed of weefsel:document:moleculair genetisch onderzoek Synonyms: KRAS gen molgen targeted
ru-RU	Russian (Russian Federation)	KRAS ген исследование на мутацию:Находка:ТчкВрм:Кр/Тк:Док:МолГен Synonyms: Документ Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент
tr-TR	Turkish (Turkey)	KRAS geni Mutasyon analizi:Bulgu:Zmlı:Kan/Dk:Dokm:Molgen
uk-UA	Ukrainian (Ukraine)	ген KRAS аналіз мутації:Знахідка:МоментЧасу:Кров/Тканини:Документ:Молекулярна генетика Synonyms: Blood; CFC2; C-K-RAS; Document; Finding; Findings; Genetics; Heredity; Heritable; Inherited; KI-RAS; Kirsten ras 1; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma virus 2; KRAS1; KRAS1P; KRAS2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; Molecular genetics; Molecular pathology; MOLPATH; MOLPATH.MUTATIONS; Mut; Mut Anl; Mutations; NS; NS3; Oncogene KRAS1; Oncogene KRAS2; PCR; Point in time; Random; RASK1; RASK2; Tissue; Tissue, unspecified; V-KI-RAS1 pseudogene; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; WB; Whole blood; Whole blood or Tissue
zh-CN	Chinese (China)	KRAS2 基因突变分析:发现:时间点:全血/组织:文档型:分子遗传学类实验室方法 Synonyms: Kirsten 大鼠肉瘤病毒 2;RASK1;RASK2;V-KI-RAS1 假基因;V-KI-RAS1 拟基因;v-Ki-ras2 Kirsten 大鼠肉瘤 2 病毒性癌基因同源基因;v-Ki-ras2 Kirsten 大鼠肉瘤 2 病毒性致癌基因同源基因;v-Ki-ras2 Kirsten 大鼠肉瘤 2 病毒癌基因同源基因;癌基因 KRAS1;癌基因 KRAS2;致癌基因 KRAS1;致癌基因 KRAS2 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书全血或组织;血液/组织;血液或组织分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论基因突变分析时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片血;血液遗传基因;遗传因子;吉恩;生物基因

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