76479-5
Acetylcholinesterase [Interpretation] in Amniotic fluid Narrative
Active
Term Description
An interpretation of the acetylcholinesterase (AChE) in amniotic fluid testing result which is used as an aid to diagnose open neural tube defect (NDT) and ventral wall defects. The two most common neural tube defects are spina bifida and anencephaly. When an NTD is suspected based upon maternal serum alpha-fetoprotein (AFP) screening results, or diagnosed via ultrasound, detection of acetylcholinesterase (AChE) in amniotic fluid is a useful diagnostic tool as normal amniotic fluid does not contain AChE, unless from the fetus as a result of an open NTD. The patient's gestational age must be at least 13 weeks (second trimester) for accurate AChE detection. Optimal gestational age is 14 to 18 weeks. If acetylcholinesterase is present genetic consultation and high-resolution ultrasound may be suggested.
Source: Regenstrief LOINC
Part Descriptions
LP15315-2 Acetylcholinesterase
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
Source: National Library of Medicine, MeSH 2006
LP15315-2 Acetylcholinesterase
Acetylcholinesterase, an enyzme (EC 3.1.1.7) (AChE) that controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine, is also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase. The ACHE gene is mapped to chromosome 7q22. AChE is found primarily in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses. Two main clinical diagnostic uses are: 1) a second trimester screening test for fetal neural tube defects using amniotic fluid and, 2) in the general population, to detect past exposure to organophosphate insecticides with resultant inhibition of the enzyme using blood.
Source: Regenstrief LOINC, Acetylcholinesterase
Fully-Specified Name
- Component
- Acetylcholinesterase
- Property
- Imp
- Time
- Pt
- System
- Amnio fld
- Scale
- Nar
- Method
Additional Names
- Short Name
- AChE Amn-Imp
- Display Name
- Acetylcholinesterase Nar (Amn fld) [Interp]
- Consumer Name Alpha Get Info
- Interpretation of Acetylcholinesterase test result, Amniotic fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 15145
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 76478-7 | Acetylcholinesterase panel - Amniotic fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Acetilcolinesterasa: |
| es-MX | Spanish (Mexico) | Acetilcolinesterasa: |
| fr-CA | French (Canada) | Acétylcholinestérase: |
| fr-FR | French (France) | Acétylcholinestérase: |
| fr-BE | French (Belgium) | Acétylcholinestérase: |
| it-IT | Italian (Italy) | Acetilcolinesterasi: Synonyms: Chimica Impressione/interpretazione di studio Liquido amniotico Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | acetylcholinesterase: |
| ru-RU | Russian (Russian Federation) | Ацетилхолинэстераза: Synonyms: Амниотическая жидкость Впечатление/интерпретация исследования Описательный Точка во времени; |
| tr-TR | Turkish (Turkey) | Asetilkolinesteraz: Synonyms: Amniyon mayii |
| zh-CN | Chinese (China) | 乙酰胆碱酯酶: Synonyms: AChE; |
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