76498-5

Cervical cells.overexpressing HPV E6+E7 mRNA/cervical cells by Flow cytometry (FC)

Active

Term Description

Detects E6/E7 mRNA in sufficient quantity to demonstrate integration and expression in ectocervical cells in cervical specimens in which high-risk HPV types have been previously been detected. (This test should only be performed on specimens found to be positive by other high-risk HPV detection methods.) Detection may identify infection more likely to progress to disease as the detection of E6/E7 is not only a sign of virus within the cell, but also evidence of viral activity and thus may help discriminate the presence of CIN2+ disease. This term was created for, but not limited in use to, the LabCorp QuantaSURE mRNA based test which measures the quantity of E6/E7 mRNA per cell and then calculates the percentage of cells that are overexpressing E6/E7 mRNA.

Part Description

LP188694-6 Cervical cells.overexpressing HPV E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Cervical cells.overexpressing HPV E6+E7 mRNA/cervical cells:NFr:Pt:Cvx:Qn:Flow cytometry
Long Common Name: Cervical cells.overexpressing HPV E6+E7 mRNA/cervical cells by Flow cytometry (FC)
Short Name: Cvx cel HPVE6+E7mRNA/Cvx cel FC-NFr
Display Name: Cervical cells.overexpressing HPV E6+E7 mRNA/cervical cells FC (Cvx)
Consumer Name Alpha Get Info: Cervical Cells.overexpressing HPV E6+E7 MRNA/cervical Cells, Cervix

Part Model Get Info

Component
Cervical cells.overexpressing HPV E6+E7 mRNA/cervical cells
LP285722-7
- Analyte
  Cervical cells.overexpressing HPV E6+E7 mRNA/cervical cells
  LP285722-7
  - Component Numerator
    Cervical cells.overexpressing HPV E6+E7 mRNA
    LP188694-6
    - Component Numerator Core
      Cervical cells.overexpressing HPV E6+E7 mRNA
      LP188694-6
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    cervical cells
    LP188695-3
    - Component Denominator Core
      cervical cells
      LP188695-3
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NFr
LP6838-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Cvx
LP7162-3
- System Core
  Cvx
  LP7162-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
Flow cytometry
LP6274-7

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.52
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 11480

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Děložní hrdlo buňky.nadexprese HPV E6+E7 mRNA/buňky děložního hrdla:Početní podíl:Časový bod:Děložní hrdlo:Kvantitativní:Průtoková cytometrie
el-GR	Greek (Greece)	Αυχενικά κύτταρα που υπερεκφράζουν HPV E6+E7 mRNA/τραχηλικά κύτταρα:NFr:Pt:Cvx:Qn:Κυτταρομετρία ροής Synonyms: Cvx MICRO NFr Pt Qn Αυχενικά κύτταρα που υπερεκφράζουν HPV E6+E7 mRNA Κύτταρα Κυτταρομετρία ροής τραχηλικά κύτταρα
es-ES	Spanish (Spain)	Celulas cervicales con sobreexpresion de mRNA HPV E6+E7/celulas cervicales:Fracción numérica:Punto temporal:Cuello uterino:Qn:Citometria de flujo (FC) Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Células cervicales que sobreexpresan ARNm de HPV E6 + E7 / células cervicales:Fracción numérica:Punto temporal:Cuello uterino:Cuantitativo:Citometría de flujo (FC)
fr-FR	French (France)	Cellules cervicales surexpression ARNm HPV E6+E7/cellules cervicales:Fraction de nombres:Ponctuel:Col de l'utérus:Numérique:Cytométrie de flux
it-IT	Italian (Italy)	Cellule cervicali.sovraesspressione di HPV E6+E7 mRNA/cellule cervicali:NFr:Pt:Cvx:Qn:Citometria a flusso Synonyms: Cervice uterina Citometria a flusso (FC) Frazione numerica Microbiologia Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	cervicale cellen.met overexpressie HPV E6+E7 mRNA/cervicale cellen:getalsfractie:moment:cervix:kwantitatief:flowcytometrie Synonyms: baarmoederhals
tr-TR	Turkish (Turkey)	Servikal hücreler.fazladan eksprese olan HPV E6+E7 mRNA/servikal hücreler:SayFr:Zmlı:Cvx:Kant:Akış sitometri Synonyms: Akış hücremetresi serviks hücreleri
zh-CN	Chinese (China)	宫颈细胞.过表达 HPV E6+E7 mRNA/宫颈细胞:计数型分数:时间点:子宫颈:定量型:流式细胞测量术 Synonyms: 动态可用数量表示的;定量性;数值型;数量型;连续数值型标尺宫颈宫颈;生殖道宫颈细胞.过表达（高表达、过度表达、过量表达、超量表达） HPV E6+E7 mRNA 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）数量型分数;数量或计数型分数;数量型分数或计数型分数时刻;随机;随意;瞬间流流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计细胞含量;细胞性;细胞性质;细胞构成;细胞类

Example Units

Unit	Source
%	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.