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Term Description

The stain is interpreted as positive if 50% or more of the tumor cells show moderate to strong (2+, 3+) membranous staining, indicating MET amplification. MET amplification (positive) has been seen in approximately 22% of non-small-cell lung cases with acquired resistance to anti-EGFR inhibitors. Recent Phase II clinical trails (OAM4558g) results were released at ASCO in 2011 showed that patients who were c-MET positive (2+ or 3+) lived twice as long without disease progression (PFS) when they received MetMAb therapy in combination with erlotinib versus receiving erlotinib alone.

Part Description

LP189738-0   Hepatocyte growth factor receptor
Hepatocyte growth factor receptor (HGFR, also known as mesenchymal-epithelial transition (MET or c-MET]) is a transmembrane tyrosine kinase receptor that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. [UniProt: P08581] The HGFR is a product of the MET gene and is important to oncogenesis and normal cellular function. It regulates many physiological processes including proliferation, scattering, morphogenesis and survival. The HGFR can be overexpressed in epithelial cancers, such as lung cancer. The overexpression of c-MET is thought to allow for cell migration and invasion leading to metastasis as well as growth advantage. PMID: 24005867 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Hepatocyte growth factor receptor Ag:PrThr:Pt:Tiss:Ord:Immune stain
Long Common Name
Hepatocyte growth factor receptor Ag [Presence] in Tissue by Immune stain
Short Name
HGFR Ag Tiss Ql ImStn
Display Name
Hepatocyte growth factor receptor Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
Hepatocyte growth factor receptor antigen, Tissue

Part Model Get Info

  • Component
    Hepatocyte growth factor receptor Ag
    LP192104-0
    • Analyte
      Hepatocyte growth factor receptor Ag
      LP192104-0
      • Component Numerator
        Hepatocyte growth factor receptor Ag
        LP192104-0
        • Component Numerator Core
          Hepatocyte growth factor receptor
          LP189738-0
        • Component Numerator Core Suffix
          Ag
          LP20666-1
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Immune stain
    LP6333-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.73 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
18014

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hepatocytový růstový faktor receptor Ag:Přítomnost nebo práh:Časový bod:Tkáně a stěry:Ordinální:Imunobarvení
el-GRGreek (Greece)Υποδοχέας ηπατοκυτταρικού αυξητικού παράγοντα Αντιγόνο:PrThr:Pt:Ιστός:Ord:Ανοσολογική χρώση
Synonyms: Ord PATH PrThr Pt Ανοσολογική χρώση Αντιγόνο Ηπατοκυτταρικός αυξητικός παράγοντας Ηπατοκύτταρο Ιστός Υποδοχέας ηπατοκυτταρικού αυξητικού παράγοντα
es-ESSpanish (Spain)Receptor del factor de crecimiento de hepatocitos Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MXSpanish (Mexico)Receptor Ag del factor de crecimiento de hepatocitos:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
fr-FRFrench (France)Facteur de croissance hépatocytaire récepteur Ag:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-ITItalian (Italy)Recettore fattore di crescita degli epatociti, Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Fattore id crescita degli epatociti Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NLDutch (Netherlands)hepatocyt groeifactorreceptor Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
Synonyms: antigeen
pl-PLPolish (Poland)Receptor czynnika wzrosu hepatocytów Ag:granica wykrywalności:punkt w czasie:tkanka i rozmazy:uporządkowany:barwienie immunohistochemiczne
Synonyms: Antygen receptora czynnika wzrostu hepatocytów Receptor czynnika wzrosu hepatocytów
tr-TRTurkish (Turkey)Hepatosit büyüme faktörü reseptörü Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama
Synonyms: Antijen Mevcut
zh-CNChinese (China)肝细胞生长因子受体 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: Ag HGFR;HGF-R 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 系数 肝实质细胞 肝细胞生长素;Hepatocyte growth factor;HGF

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77173-3