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Status Information

Status
DISCOURAGED
Comment
The Method values "Screen" and "Confirm" reflect a regulatory testing requirement rather than an actual laboratory method. This term has been discouraged in favor of terms specifying the true method (Immunoassay or Mass Spectrometry) or a methodless term where appropriate. Please select the replacement term that matches your actual testing method.

Term Description

This is a confirmatory test for the presence of norbuprenorphine, a metabolite of buprenorphine, in saliva. The result is reported as positive or negative based on the quantitative result.

Part Descriptions

LP34568-3   Norbuprenorphine
Buprenorphine (tradename Buprenex), is a long-lasting, high affinity opioid that acts on the same receptors as heroin and morphine but does not produce the same intense high or dangerous side effects. It is used for the treatment of pain and opioid dependence. The major buprenorphine metabolites are norbuprenorphine, buprenorphine-3-glucuronide (B3G), and norbuprenorphine-3-glucuronide (N3G). The analysis of buprenorphine and metabolites is performed to monitor compliance to drug therapy. Source: Regenstrief LOINC

LP34568-3   Norbuprenorphine
Norbuprenorphine is the primary active metabolite of buprenorphine, and its mean steady-state plasma concentration is comparable to or even exceeds that of buprenorphine following sublingual buprenorphine absorption (Kuhlman et al., 1998). It is likely to contribute to the overall pharmacological effects of buprenorphine. Buprenorphine and norbuprenorphine displayed distinct pharmacological properties at mu-opioid, delta-opioid, and kappa-opioid receptors and the ORL1 receptor. PMID: 11303059 Source: Regenstrief LOINC

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

LP262420-5   Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. PMID: 17268583 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Norbuprenorphine:PrThr:Pt:Saliva:Ord:Confirm
Long Common Name
Norbuprenorphine [Presence] in Saliva (oral fluid) by Confirmatory method
Short Name
Norbuprenorphine Sal Ql Cfm
Display Name
Norbuprenorphine Confirm Ql (Sal)
Consumer Name Alpha Get Info
Norbuprenorphine, Saliva

Part Model Get Info

  • Component
    Norbuprenorphine
    LP34568-3
    • Analyte
      Norbuprenorphine
      LP34568-3
      • Component Numerator
        Norbuprenorphine
        LP34568-3
        • Component Numerator Core
          Norbuprenorphine
          LP34568-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Saliva
    LP7565-7
    • System Core
      Saliva
      LP7565-7
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Confirm
    LP6197-0

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.83 (MIN)
Change Reason
Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.;
Order vs. Observation
Observation
Common Test Rank Get Info
11450

Member of these Groups Get Info

LOINC GroupGroup Name
LG50147-4Norbuprenorphine|ANYProp|ANYTm|ANYSys|ANYMeth

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Norbuprenorfin:Přítomnost nebo práh:Časový bod:Sliny:Ordinální:Konfirmace
el-GRGreek (Greece)Νορβουπρενορφίνη:PrThr:Pt:Σίελος:Ord:Επιβεβαίωση
Synonyms: DRUG/TOX Ord PrThr Pt Επιβεβαίωση Νορβουπρενορφίνη Σίελος
es-ESSpanish (Spain)Norbuprenorfina:PrThr:Punto temporal:Saliva:Ord:Confirmatorio
es-MXSpanish (Mexico)Norbuprenorfina:Presencia o umbral:Punto temporal:Saliva:Ordinal:Confirmar
et-EEEstonian (Estonia)Norbuprenorfiin:PrThr:Pt:Sal:Ord:Kinnitav
Synonyms: Järgarvuline Juhuslik Sülg
fr-CAFrench (Canada)Norbuprénorphine:Présence-Seuil:Temps ponctuel:Salivaire:Ordinal:Confirmation
fr-FRFrench (France)Norbuprénorphine:Présence/Seuil:Ponctuel:Salive:Qualitatif:Confirmation
fr-BEFrench (Belgium)Norbuprenorphine:PrThr:Temps ponctuel:Salivaire:Ordinal:Confirmé
it-ITItalian (Italy)Norbuprenorfina:PrThr:Pt:Saliva:Ord:Conferma
Synonyms: Livelli farmacologici e tossicologia Presenza o Soglia Punto nel tempo (episodio)
nl-NLDutch (Netherlands)norbuprenorfine:aanwezigheid:moment:speeksel:ordinaal:bevestiging
ru-RURussian (Russian Federation)Норбупренорфин:PrThr:ТчкВрм:Слюна:Пор:Подтверждать
Synonyms: Порядковый Точка во времени;Момент
tr-TRTurkish (Turkey)Norbuprenorfin:MevcEşik:Zmlı:Tükürük:Srl:Onay
Synonyms: Mevcut Teyid
zh-CNChinese (China)去甲基丁丙诺啡:存在情况或阈值:时间点:唾液:序数型:毒理学确认试验
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 毒品 毒品类 津;津液;涎 确认方法;确认法;确认试验 脱甲基丁丙诺啡;丁丙诺啡代谢产物;去甲丁丙诺啡;去甲基布诺啡;去甲布诺啡 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77206-1