77349-9
Everolimus [Mass/volume] in Blood by LC/MS/MS --trough
Active
Term Description
Trough blood levels of everolimus is performed for therapeutic monitoring and dose individualization. Koster et. al. (2009) reported a systematic deviation in blood levels of everolimus (30% lower) measured by LC-MS/MS compared with immunoassays. PMID: 19065123 Everolimus may be used to treat patients post transplant (e.g, kidney transplant) or with tuberous sclerosis complex (TSC) who have subependymal giant cell astrocytoma (SEGA). Maintaining everolimus troughs between 3-8 ng/mL is recommended for patients post transplant. Maintaining trough levels of 5 to 15 ng/mL is recommended in pediatric and adult patients with SEGA.
Source: Regenstrief LOINC
Part Descriptions
LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety.
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Source: Wikipedia, Trough levels for therapeutic drug monitoring
LP65523-0 Everolimus
Everolimus is a kinase inhibitor that is used to treat a number of cancers and to prevent rejection of organ transplants. It is an mTOR inhibitor, and has been effective against renal cell carcinoma, pancreatic neuroendocrine tumors, and advanced kidney tumors, all of which have been unsuccessfully treated with other medications. [MedlinePlus:druginfo/meds/a609032] [NCI:about-cancer/treatment/drugs/fda-everolimus] PMCID: PMC4385860
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Everolimus^trough
- Property
- MCnc
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
- LC/MS/MS
Additional Names
- Short Name
- Everolimus Trough Bld LC/MS/MS-mCnc
- Display Name
- Everolimus trough LC/MS/MS (Bld) [Mass/Vol]
- Consumer Name Alpha Get Info
- Everolimus trough, Blood
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 10395
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG27729-9 | Everolimus^trough| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Everolimus ^ canal: |
| es-ES | Spanish (Spain) | Everolimus^Valle monitorización terapéutica de fármacos: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Everoliimus^baas: Synonyms: Juhuslik Kvantitatiivne Veri |
| fr-FR | French (France) | Évérolimus taux résiduel: |
| fr-BE | French (Belgium) | Everolimus^Creux: Synonyms: Minimum, nadir |
| it-IT | Italian (Italy) | Everolimus^valore minimo: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Punto nel tempo (episodio) Sangue valore minimo TDM |
| nl-NL | Dutch (Netherlands) | everolimus^dalspiegel: |
| tr-TR | Turkish (Turkey) | Everolimus^en düşük: Synonyms: çukur düzey |
| zh-CN | Chinese (China) | 依维莫司^波谷: Synonyms: 40-O-(2-羟乙基)-西罗莫司; |
Example Units
| Unit | Source |
|---|---|
| ng/mL | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
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LOINC Copyright
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