Version 2.80

Term Description

This term was created for, but not limited in use to, the Roche cobas total P1NP, total procollagen type 1 amino-terminal propeptide test kit.

Part Descriptions

LP57671-7   Procollagen type I.N-terminal propeptide
A procollagen peptide contains an additional peptide sequence, termed the propeptide, at its amino and carboxy terminal ends. Collagen types I, II, III, IV and V are synthesized as precursor molecules called procollagens. Propeptides facilitate the winding of procollagen molecules into a triple-helix conformation within the endoplasmic reticulum. These propeptides are then cleaved from the collagen triple helix molecule during its secretion, after which the collagens polymerize into extracellular collagen fibrils. Thus, the amount of free propeptides directly correlates with collagen molecule synthesis. Procollagen Type I C-peptide (PIP) has also been extensively referenced in correlation studies between collagen levels and certain health disorders such as bone disease, alcoholic liver disease, liver cirrhosis and cirrhosis (Borrmann type IV) adenocarcinoma of the stomach. Source: Regenstrief Help

LP57671-7   Procollagen type I.N-terminal propeptide
Procollagen type I N-terminal propeptide is considered a sensitive marker of bone formation and it is particularly useful for monitoring treatment for osteoporosis in postmenopausal women, and Paget's disease of the bone. Type I collagen constitutes 90% of bone proteins and is synthesized as type I procollagen. During the extracellular processing of type I procollagen, the amino terminal [N-terminal propeptide of type I collagen] and carboxy terminal propeptide are separated. These propeptides circulate in the bloodstream, where they are markers of bone formation. Procollagen type I N-terminal propeptide circulates as different forms, including the intact authentic trimeric procollagen type I N-terminal propeptide, a monomer, and several fragments. PMID: 17998267 Source: Regenstrief LOINC , PMID: 17998267

Fully-Specified Name

Component
Procollagen type I.N-terminal propeptide
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Long Common Name
Procollagen type I.N-terminal propeptide [Mass/volume] in Serum or Plasma by Immunoassay
Short Name
PINP SerPl IA-mCnc
Display Name
Procollagen type I.N-terminal propeptide IA [Mass/Vol]
Consumer Name Alpha Get Info
Procollagen Type I.N-terminal Propeptide, Blood

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.56 (MIN)
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG18642-5 Procollagen type I.N-terminal propeptide|MCnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Prokollagenpeptid Typ 1.Propeptid N-Terminal:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:Immunoassay
el-GR Greek (Greece) Προκολλαγόνο τύπου I.N-τερματικό προπεπτίδιο:MCnc:Pt:Ορός/Πλάσμα:Qn:IA
Synonyms: I MCnc N Type Προκολλαγόνο τύπου I Προκολλαγόνο τύπου I.N-τερματικό προπεπτίδιο
es-ES Spanish (Spain) Péptido N-terminal del procolágeno tipo I:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Propéptido N-terminal de procolágeno tipo I.:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
et-EE Estonian (Estonia) I tüüpi prokollageeni N-fragment:MCnc:Pt:S/P:Qn:IA
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Procollagène type I.N-terminal propeptide:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
fr-FR French (France) Procollagène type 1 propeptide N terminal:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
fr-BE French (Belgium) Peptide du procollagène.type 1 N-terminal:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
Synonyms: PNPP-1
it-IT Italian (Italy) Procollagene, peptide.tipo 1 N-Terminale:MCnc:Pt:Siero/Plasma:Qn:IA
Synonyms: Chimica Concentrazione di Massa Immunoassay Peptide del procollagene di tipo 1 Peptide del procollagene di tipo 1 N-Terminale Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) procollageenpeptide.type 1 N-terminaal:massa/volume:moment:serum of plasma:kwantitatief:immunoassay
Synonyms: IA soort
ru-RU Russian (Russian Federation) Проколлаген пептид.тип 1 N-Терминаль:МассКонц:ТчкВрм:Сыв/Плаз:Колич:IA
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Prokollajen peptid.tip 1 N-Terminal:KütlKons:Zmlı:Ser/Plaz:Kant:İA
Synonyms: İmmünölçüm, immünoassay
zh-CN Chinese (China) 前胶原肽.I 型 N-末端:质量浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: 1 型前胶原肽 N-末端;1 型前胶原肽氨基末端;I 型前胶原肽 N-末端;I 型前胶原肽氨基末端;P1NP;PINP;前胶原肽.1 型 氨基末端;前胶原肽.1 型 N-末端;前胶原肽.I 型 氨基末端 I 型 N 型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 前胶原.I 型;前胶原肽.1 型;1 型前胶原肽;1 型原骨胶原肽;1 型溶胶原肽;1 型酸溶原胶原蛋白肽;1 型酸溶胶原蛋白肽;I 型前胶原肽;I 型原骨胶原肽;I 型溶胶原肽;I 型酸溶原胶原蛋白肽;I 型酸溶胶原蛋白肽;前胶原肽.I 型;原骨胶原肽.1 型;原骨胶原肽.I 型;溶胶原肽.1 型;溶胶原肽.I 型;酸溶原胶原蛋白肽.1 型;酸溶原胶原蛋白肽.I 型;酸溶胶原蛋白肽.1 型;酸溶胶原蛋白肽.I 型 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 型 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77370-5