Version 2.80

Term Description

Timed cortisol levels are obtained for adrenocorticotropic hormone challenge tests to assist in diagnosing adrenocortical insufficiency as found in Cushing's syndrome and Addison's disease. There are different types of challenges. ACTH (adrenocorticotropic hormone) stimulation, where cosyntropin (a synthetic form of ACTH) is given, and then blood is sampled for cortisol levels before the bolus, and at specified times after the bolus. The ACTH stimulation directly evaluates adrenal gland function and indirectly evaluates pituitary gland and hypothalamus function. Cortisol levels rise significantly after administration of cosyntropin if the adrenal glands are functioning normally. For the CRH (corticotropin-releasing hormone) stimulation, CRH is given and cortisol and ACTH levels are determined before the injection, at the injection time, and specified times following injection. The CRH stimulation test is used to distinguish Cushings disease from conditions where ACTH is secreted ectopically. For the Dexamethasone suppression (overnight) test (DST), dexamethasone (Decadron) is given and samples for cortisol levels are collected the following morning. The DST differentiates the causes of increased cortisol levels. For the Metyrapone (overnight) stimulation challenge, metyrapone is given with a snack at midnight. Samples for cortisol, 11-deoxycortisol, and ACTH are collected the following morning. The metyrapone stimulation test distinguishes corticotropin-dependent causes (pituitary Cushing's disease and ectopic Cushing's disease) from corticotropin-independent causes (carcinoma of the lung or thyroid) of increased cortisol levels.

Part Description

LP14161-1   Cortisol
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

Fully-Specified Name

Component
Cortisol^1M post XXX challenge
Property
SCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Long Common Name
Cortisol [Moles/volume] in Serum or Plasma --1 minute post XXX challenge
Short Name
Cortis 1M p chal SerPl-sCnc
Display Name
Cortisol 1 Min post Unsp challenge [Moles/Vol]
Consumer Name Alpha Get Info
Cortisol 1 min after challenge, Blood

Basic Attributes

Class
CHAL
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.58 (MIN)
Order vs. Observation
Observation

Member of these Groups Get Info

LOINC Group Group Name
LG50527-7 Cortisol^1M post XXX challenge|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κορτιζόλη^1 λεπτά κατόπιν πρόκλησης XXX:SCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: SCnc Κορτιζόλη Πρόκληση
es-ES Spanish (Spain) Cortisol^1 minuto pos provocación con XXX:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cortisol ^1 M después del desafío XXX:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
et-EE Estonian (Estonia) Kortisool^1 minut pärast XXX manustamist:SCnc:Pt:S/P:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Cortisol^1 min post test de provocation XXX:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FR French (France) Cortisol T01min après épreuve:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Cortisol^1 min post test de provocation XXX:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Cortisolo^1Minuto post XXX provocazione:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: 1 minuto dopo XXX stimolo Concentrazione di Sostanza dopo XXX provocazione Plasma Punto nel tempo (episodio) Siero Siero o Plasma Stimolo Test di provocazione
nl-NL Dutch (Netherlands) cortisol^1 min na XXX belasting:mol/volume:moment:serum of plasma:kwantitatief:
Synonyms: 1M na XXX belasting
ru-RU Russian (Russian Federation) Кортизол^1 минута после XXX пробы:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Молярность;Молярная объёмная концентрация Плазма Провокационная проба Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Kortizol^1dk snr XXX girişimi:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CN Chinese (China) 皮质醇^在XXX刺激之后1分钟:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 17-羟皮质甾酮;17-羟皮质酮;化合物 F;可的索;氢化可的松;皮质甾醇;考的索 1Min之后于XXX刺激;1Min之后于此处不作说明的刺激;1分钟之后于XXX刺激;1分钟之后于此处不作说明的刺激;60Sec之后于XXX刺激;60Sec之后于此处不作说明的刺激;60秒钟之后于XXX刺激;60秒钟之后于此处不作说明的刺激;在XXX刺激之后1Min;在XXX刺激之后60Sec;在XXX刺激之后60秒钟;在此处不作说明的刺激之后1Min;在此处不作说明的刺激之后1分钟;在此处不作说明的刺激之后60Sec;在此处不作说明的刺激之后60秒钟 XXX刺激 - 在...之后 XXX刺激因素 之后于 XXX 刺激;之后于 XXX 刺激因素;之后于此处不作说明的刺激;之后于此处不作说明的刺激因素;在 XXX 刺激因素之后;在此处不作说明的刺激之后;在此处不作说明的刺激因素之后 之后于... 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 刺激因素;挑战 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 在...以后 在后 时刻;随机;随意;瞬间 此处不作说明的刺激 此处不作说明的刺激因素 血清或血浆

Example Units

Unit Source
nmol/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77607-0