Version 2.77

Term Description

Brain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) are significantly elevated in patients with heart failure because tension or stretching of the cardiac wall, such as occurs with heart failure, stimulates the synthesis of natriuretic peptides. Pleural fluid BNP and NT-proBNP is a useful biomarker for pleural effusions secondary to heart failure. A pleural NT-proBNP cutoff value of 1,165 pg/mL had a sensitivity of approximately 95% for discriminating heart failure-related effusions from exudates, and a cutoff of 2,300 pg/mL had a sensitivity of approximately 70% for discriminating heart failure-related transudates from non-heart-failure related pleural effusions. PMID: 22710710 This term was created for, but is not restricted in use to, the Elecsys proBNP II assay, which contains two monoclonal antibodies that recognize epitopes located in the N-terminal part (1-76) of proBNP (1-108).
Source: Regenstrief LOINC

Part Description

LP31268-3   Natriuretic peptide.B prohormone N-Terminal
ProBNP is the 108 amino acid pro-hormone of BNP (Brain Naturetic Peptide) that is produced mainly in the left ventricle. The prohormone splits into two polypeptides- the biologically active but shorter BNP (77-108) and the longer N terminal (1-76) fragment called NT-proBNP. Commercial assays are available for NT-proBNP because of its usefulness in predicting cardiovascular risk. In one study, it was the single best predictor of survival among patients with the acute coronary syndrome. It also declines with successful treatment of left ventricular dysfunctionand heart failure and is used by some to track the success of such treatment. No commercial assays exist for proBNP (the whole peptide)- though the trade name for one companies NT-proBNP is "proBNP" -- a misnomer. We include proBNP as the a related name for NT-proBNP so that people who call it proBNP will find it in LOINC. Source: Regenstrief Help

Fully-Specified Name

Component
Natriuretic peptide.B prohormone N-Terminal
Property
MCnc
Time
Pt
System
Plr fld
Scale
Qn
Method
IA

Additional Names

Short Name
NT-proBNP Plr IA-mCnc
Display Name
Natriuretic peptide.B prohormone N-Terminal IA (Pleur fld) [Mass/Vol]
Consumer Name Alpha Get Info
Natriuretic Peptide.B Prohormone N-Terminal, Pleural fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.56
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Prohormona N-Terminal. Péptido natriurético tipo B:Concentración de masa:Punto temporal:Líquido pleural:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Péptido natriurético B prohormona N-Terminal:Concentración de masa:Punto temporal:Líquido pleural:Cuantitativo:Inmunoensayo
et-EE Estonian (Estonia) B-tüüpi natriureetiline propeptiid:MCnc:Pt:PlrF:Qn:IA
Synonyms: Juhuslik Kvantitatiivne Pleuravedelik
fr-CA French (Canada) Peptide natriurétique.prohormone B N-terminale:Concentration de masse:Temps ponctuel:Liquide pleural:Quantitatif:IA
fr-FR French (France) NT-Pro brain natriuretic peptide:Masse/Volume:Ponctuel:Liquide pleural:Numérique:Immunoanalyse
fr-BE French (Belgium) Peptide natriurétique.prohormone B N-terminale:Concentration de masse:Temps ponctuel:Liquide pleural:Quantitatif:IA
Synonyms: BNP NT-proBNP
it-IT Italian (Italy) Peptide natriuretico.proormone B N-Terminale:MCnc:Pt:Liquido pleurico:Qn:IA
Synonyms: Chimica Concentrazione di Massa Immunoassay Liquido pleurico Peptide natriuretico B Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) natriuretisch peptide.B prohormoon N-terminaal:massa/volume:moment:pleuravocht:kwantitatief:immunoassay
Synonyms: IA
ru-RU Russian (Russian Federation) Натрийуретический пептид.B прогормон N-терминаль:МассКонц:ТчкВрм:Плевр ждк:Колич:IA
Synonyms: Количественный Массовая концентрация Плевральная жидкость Точка во времени;Момент
tr-TR Turkish (Turkey) Natriüretik peptid.B prohormon N-Terminal:KütlKons:Zmlı:Plvr sv:Kant:İA
Synonyms: İmmünölçüm, immünoassay
zh-CN Chinese (China) 利钠肽.B 激素原 N-末端:质量浓度:时间点:胸膜液:定量型:免疫测定法
Synonyms: B 型 B 型利钠肽;B 型尿钠肽;B 型钠尿肽;B 型钠素;Beta 利钠肽;Beta 利钠肽(Beta Natriuretic Peptide,Brain Natriuretic Peptide,B-type natriuretic peptide,BNP);BNP;BNP 属于心肌细胞及其他细胞产生的一个结构类似的肽类家族。心脏产生有两种类型的利钠蛋白:A-型利钠肽 (ANP) (完全由心房心肌细胞产生) 和 B-型利钠肽 (BNP) 。心房和心室心肌细胞均可制造 ANP。BNP 并不伴随着心脏应激状态 ( N 型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 利钠肽.B 激素原氨基末端;利钠肽.B 激素原;B 型利钠肽激素原;B 型尿钠肽激素原;B 型钠尿肽激素原;B 型钠素激素原;Beta 型利钠肽激素原;BNP;NT-proBNP;proBNP;β型利钠肽激素原;与 同样是测定药物 Natrecor 的 BNP 相反,B 型利钠肽激素原是心脏所释放的脑利尿钠肽的形式;尿钠肽.B 激素原;脑利尿钠肽激素原;钠尿肽.B 激素原;钠素.B 激素原 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 缩氨酸 胸腔积液;胸水;胸膜穿刺液;胸膜腔积水;胸膜腔积液

Example Units

Unit Source
ng/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77621-1