77621-1
Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Pleural fluid by Immunoassay
Active
Term Description
Brain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) are significantly elevated in patients with heart failure because tension or stretching of the cardiac wall, such as occurs with heart failure, stimulates the synthesis of natriuretic peptides. Pleural fluid BNP and NT-proBNP is a useful biomarker for pleural effusions secondary to heart failure. A pleural NT-proBNP cutoff value of 1,165 pg/mL had a sensitivity of approximately 95% for discriminating heart failure-related effusions from exudates, and a cutoff of 2,300 pg/mL had a sensitivity of approximately 70% for discriminating heart failure-related transudates from non-heart-failure related pleural effusions. PMID: 22710710 This term was created for, but is not restricted in use to, the Elecsys proBNP II assay, which contains two monoclonal antibodies that recognize epitopes located in the N-terminal part (1-76) of proBNP (1-108).
Source: Regenstrief LOINC
Part Description
LP31268-3 Natriuretic peptide.B prohormone N-Terminal
ProBNP is the 108 amino acid pro-hormone of BNP (Brain Naturetic Peptide) that is produced mainly in the left ventricle. The prohormone splits into two polypeptides- the biologically active but shorter BNP (77-108) and the longer N terminal (1-76) fragment called NT-proBNP. Commercial assays are available for NT-proBNP because of its usefulness in predicting cardiovascular risk. In one study, it was the single best predictor of survival among patients with the acute coronary syndrome. It also declines with successful treatment of left ventricular dysfunctionand heart failure and is used by some to track the success of such treatment. No commercial assays exist for proBNP (the whole peptide)- though the trade name for one companies NT-proBNP is "proBNP" -- a misnomer. We include proBNP as the a related name for NT-proBNP so that people who call it proBNP will find it in LOINC.
Source: Regenstrief Help
Fully-Specified Name
- Component
- Natriuretic peptide.B prohormone N-Terminal
- Property
- MCnc
- Time
- Pt
- System
- Plr fld
- Scale
- Qn
- Method
- IA
Additional Names
- Short Name
- NT-proBNP Plr IA-mCnc
- Display Name
- Natriuretic peptide.B prohormone N-Terminal IA (Pleur fld) [Mass/Vol]
- Consumer Name Alpha Get Info
- Natriuretic Peptide.B Prohormone N-Terminal, Pleural fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.56
- Change Reason
- The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Prohormona N-Terminal. Péptido natriurético tipo B: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Péptido natriurético B prohormona N-Terminal: |
et-EE | Estonian (Estonia) | B-tüüpi natriureetiline propeptiid: Synonyms: Juhuslik Kvantitatiivne Pleuravedelik |
fr-CA | French (Canada) | Peptide natriurétique.prohormone B N-terminale: |
fr-FR | French (France) | NT-Pro brain natriuretic peptide: |
fr-BE | French (Belgium) | Peptide natriurétique.prohormone B N-terminale: Synonyms: BNP NT-proBNP |
it-IT | Italian (Italy) | Peptide natriuretico.proormone B N-Terminale: Synonyms: Chimica Concentrazione di Massa Immunoassay Liquido pleurico Peptide natriuretico B Punto nel tempo (episodio) |
nl-NL | Dutch (Netherlands) | natriuretisch peptide.B prohormoon N-terminaal: Synonyms: IA |
ru-RU | Russian (Russian Federation) | Натрийуретический пептид.B прогормон N-терминаль: Synonyms: Количественный Массовая концентрация Плевральная жидкость Точка во времени; |
tr-TR | Turkish (Turkey) | Natriüretik peptid.B prohormon N-Terminal: Synonyms: İmmünölçüm, immünoassay |
zh-CN | Chinese (China) | 利钠肽.B 激素原 N-末端: Synonyms: B 型 B 型利钠肽; |
Example Units
Unit | Source |
---|---|
ng/L | Example UCUM Units |
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