Version 2.77

Term Description

Brain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) are significantly elevated in patients with heart failure because tension or stretching of the cardiac wall, such as occurs with heart failure, stimulates the synthesis of natriuretic peptides. Elevated levels are associated with adverse outcomes in both hemodialysis (HD) and peritoneal dialysis (PD) patients and are attributable to both ventricular dysfunction and decreased renal clearance. Peritoneal dialysate and plasma NT-proBNP levels are linearly related. PMID: 21427249 This term was created for, but is not restricted in use to, the Elecsys proBNP II assay, which contains two monoclonal antibodies that recognize epitopes located in the N-terminal part (1-76) of proBNP (1-108).
Source: Regenstrief LOINC

Part Description

LP31268-3   Natriuretic peptide.B prohormone N-Terminal
ProBNP is the 108 amino acid pro-hormone of BNP (Brain Naturetic Peptide) that is produced mainly in the left ventricle. The prohormone splits into two polypeptides- the biologically active but shorter BNP (77-108) and the longer N terminal (1-76) fragment called NT-proBNP. Commercial assays are available for NT-proBNP because of its usefulness in predicting cardiovascular risk. In one study, it was the single best predictor of survival among patients with the acute coronary syndrome. It also declines with successful treatment of left ventricular dysfunctionand heart failure and is used by some to track the success of such treatment. No commercial assays exist for proBNP (the whole peptide)- though the trade name for one companies NT-proBNP is "proBNP" -- a misnomer. We include proBNP as the a related name for NT-proBNP so that people who call it proBNP will find it in LOINC. Source: Regenstrief Help

Fully-Specified Name

Component
Natriuretic peptide.B prohormone N-Terminal
Property
MCnc
Time
Pt
System
Dial fld prt
Scale
Qn
Method
IA

Additional Names

Short Name
NT-proBNP DiafP IA-mCnc
Display Name
Natriuretic peptide.B prohormone N-Terminal IA (Perit dial fld) [Mass/Vol]
Consumer Name Alpha Get Info
Natriuretic Peptide.B Prohormone N-Terminal, Peritoneal dialysis fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.56
Change Reason
The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Prohormona N-Terminal. Péptido natriurético tipo B:Concentración de masa:Punto temporal:Dialisis líquido peritoneal:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Péptido natriurético B prohormona N-Terminal:Concentración de masa:Punto temporal:Líquido de diálisis peritoneal:Cuantitativo:Inmunoensayo
et-EE Estonian (Estonia) B-tüüpi natriureetiline propeptiid:MCnc:Pt:DiaF:Qn:IA
Synonyms: Dialüüsivedelik Juhuslik Kvantitatiivne
fr-CA French (Canada) Peptide natriurétique.prohormone B N-terminale:Concentration de masse:Temps ponctuel:Solution de dialyse péritonéale:Quantitatif:IA
fr-FR French (France) NT-Pro brain natriuretic peptide:Masse/Volume:Ponctuel:Liquide de dialyse péritonéale:Numérique:Immunoanalyse
fr-BE French (Belgium) Peptide natriurétique.prohormone B N-terminale:Concentration de masse:Temps ponctuel:Solution de dialyse péritonéale:Quantitatif:IA
Synonyms: BNP NT-proBNP
it-IT Italian (Italy) Peptide natriuretico.proormone B N-Terminale:MCnc:Pt:Liquido di dialisi peritoneale:Qn:IA
Synonyms: Chimica Concentrazione di Massa Dialisato Immunoassay Liquido di dialisi peritoneale Peptide natriuretico B Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) natriuretisch peptide.B prohormoon N-terminaal:massa/volume:moment:periteonale dialysevloeistof:kwantitatief:immunoassay
Synonyms: IA
ru-RU Russian (Russian Federation) Натрийуретический пептид.B прогормон N-терминаль:МассКонц:ТчкВрм:Диал ждк перитон:Колич:IA
Synonyms: Диализная жидкость Количественный Массовая концентрация Точка во времени;Момент
tr-TR Turkish (Turkey) Natriüretik peptid.B prohormon N-Terminal:KütlKons:Zmlı:Diyal sv prt:Kant:İA
Synonyms: İmmünölçüm, immünoassay
zh-CN Chinese (China) 利钠肽.B 激素原 N-末端:质量浓度:时间点:腹膜透析液:定量型:免疫测定法
Synonyms: B 型 B 型利钠肽;B 型尿钠肽;B 型钠尿肽;B 型钠素;Beta 利钠肽;Beta 利钠肽（Beta Natriuretic Peptide，Brain Natriuretic Peptide，B-type natriuretic peptide，BNP）;BNP;BNP 属于心肌细胞及其他细胞产生的一个结构类似的肽类家族。心脏产生有两种类型的利钠蛋白：A-型利钠肽 (ANP) (完全由心房心肌细胞产生) 和 B-型利钠肽 (BNP) 。心房和心室心肌细胞均可制造 ANP。BNP 并不伴随着心脏应激状态 ( N 型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 利钠肽.B 激素原氨基末端;利钠肽.B 激素原;B 型利钠肽激素原;B 型尿钠肽激素原;B 型钠尿肽激素原;B 型钠素激素原;Beta 型利钠肽激素原;BNP;NT-proBNP;proBNP;β型利钠肽激素原;与 同样是测定药物 Natrecor 的 BNP 相反，B 型利钠肽激素原是心脏所释放的脑利尿钠肽的形式;尿钠肽.B 激素原;脑利尿钠肽激素原;钠尿肽.B 激素原;钠素.B 激素原 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 渗析液;透析物 缩氨酸

Example Units

Unit Source
ng/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77622-9