Version 2.78

Term Description

The interpretation for RT-PCR detection of full length and truncated gene variants of the erm(41) gene unique to Mycobacterium abscessus complex (M. abscessus, M. massiliense, and M. bolletii) from clinical isolates. The presence of a full length functional erm(41)gene confers inducible resistance to clarithromycin while the non-functional truncated erm(41) gene exhibits higher drug susceptibility. PMID: 22290346
Source: Regenstrief LOINC

Part Description

LP190749-4   Mycobacterium abscessus complex clarithromycin resistance erm(41) gene
The M. abscessus complex consists of three subspecies (M. abscessus subsp. Abscessus, M. abscessus subsp. Massiliense, M. abscessus subsp. Bolletii). PMID: 22403419 They are known to cause respiratory disease in cystic fibrosis and elderly patients as well as skin and soft tissue infections. PMID: 25106861 M. abscessus infections are often difficult to treat as many strains are resistant to most of the common antibiotics. Their resistance to clarithromycin can be determined based on expression of the inducible ribomethylase gene, erm(41). The presence of a full length functional erm(41)gene, which is specific for M. abscessus, confers inducible resistance to clarithromycin while the non-functional truncated erm(41) gene exhibits higher drug susceptibility. PMID: 22290346 Real-time PCR methods are performed to detect the presence of the full or truncated erm(41) gene and determine proper treatment for patients. Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium abscessus complex clarithromycin resistance erm(41) gene
Property
Imp
Time
Pt
System
Isolate/Specimen
Scale
Nom
Method
Molgen

Additional Names

Long Common Name
Mycobacterium abscessus complex clarithromycin resistance erm(41) gene [Interpretation] by Molecular method
Short Name
M abscessus erm(41) Islt/Spm-Imp
Display Name
M. abscessus complex clarithromycin resistance erm(41) gene Molgen (Islt/Spec) [Interp]
Consumer Name Alpha Get Info
Mycobacterium abscessus complex clarithromycin resistance erm(41) gene

Example Answer List: LL3595-7

Source: New York State Health (Wadsworth Center)
Answer Code Score Answer ID
Not detected LA11883-8
Full length erm(41) present, suggests inducible clarithromycin resistance. Culture is required to confirm these results. LA23797-6
Truncated erm(41) present, suggests clarthromycin susceptibility. Culture is required to confirm these results. LA23798-4

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.65
Change Reason
Removed parentheses around "erm(41)" in Component based on our current LOINC model.; Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
77737-5 Mycobacterium abscessus complex clarithromycin resistance erm(41) gene panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium-abscessus-Komplex Clarithromycin-Resistenz erm(41)-Gen:Interpretation:Zeitpunkt:Isolat oder Probenmaterial:Nominal:Molekulargenetisch
es-ES Spanish (Spain) Mycobacterium abscessus complex resistente a claritromicina (erm(41)) gen:Impresión/interpretación del estudio:Punto temporal:Muestra aislada:Nom:Genética molecular
es-MX Spanish (Mexico) Gen erm (41) de resistencia a claritromicina del complejo Mycobacterium abscessus:Impresión / interpretación del estudio:Punto temporal:Aislado o espécimen:Nominal:Genética molecular
fr-FR French (France) Mycobacterium complexe abscessus résistance à la clarithromycine erm(41) gène:Interprétation:Ponctuel:Isolat/échantillon:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) Complesso Mycobacterium abscessus claritromicina resistente, gene (erm(41)):Imp:Pt:Isolato/Campione:Nom:Molgen
Synonyms: Genetica molecolare Impressione/interpretazione di studio Isolato o Campione Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium abscessus complex clarithromycine-resistent (erm(41)) gen:interpretatie:moment:isolaat of monster:nominaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 脓肿分枝杆菌复合体克拉霉素耐药 erm(41) 基因:印象:时间点:分离株/标本:名义型:分子遗传学类实验室方法
Synonyms: AFB 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 劳瘵 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 受检物 复合体 大环内酯类抗生素;第二代红霉素 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 结核 结核病 耐性 肺结核 脓肿分枝杆菌（脓肿分支杆菌、化脓性分枝杆菌、化脓性分支杆菌）复合体（复合物）克拉霉素耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）erm(41) 基因 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77736-7