77933-0
Cortisol [Moles/volume] in Serum or Plasma --9 hours post XXX challenge
Active
Term Description
Timed cortisol levels are obtained for adrenocorticotropic hormone challenge tests to assist in diagnosing adrenocortical insufficiency as found in Cushing's syndrome and Addison's disease. There are different types of challenges. ACTH (adrenocorticotropic hormone) stimulation, where cosyntropin (a synthetic form of ACTH) is given, and then blood is sampled for cortisol levels before the bolus, and at specified times after the bolus. The ACTH stimulation directly evaluates adrenal gland function and indirectly evaluates pituitary gland and hypothalamus function. Cortisol levels rise significantly after administration of cosyntropin if the adrenal glands are functioning normally. For the CRH (corticotropin-releasing hormone) stimulation, CRH is given and cortisol and ACTH levels are determined before the injection, at the injection time, and specified times following injection. The CRH stimulation test is used to distinguish Cushings disease from conditions where ACTH is secreted ectopically. For the Dexamethasone suppression (overnight) test (DST), dexamethasone (Decadron) is given and samples for cortisol levels are collected the following morning. The DST differentiates the causes of increased cortisol levels. For the Metyrapone (overnight) stimulation challenge, metyrapone is given with a snack at midnight. Samples for cortisol, 11-deoxycortisol, and ACTH are collected the following morning. The metyrapone stimulation test distinguishes corticotropin-dependent causes (pituitary Cushing's disease and ectopic Cushing's disease) from corticotropin-independent causes (carcinoma of the lung or thyroid) of increased cortisol levels.
Part Description
LP14161-1 Cortisol
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma.
Source: Regenstrief Help
Fully-Specified Name
- Component
- Cortisol^9H post XXX challenge
- Property
- SCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Long Common Name
- Cortisol [Moles/volume] in Serum or Plasma --9 hours post XXX challenge
- Short Name
- Cortis 9h p chal SerPl-sCnc
- Display Name
- Cortisol 9 Hr post Unsp challenge [Moles/Vol]
- Consumer Name Alpha Get Info
- Cortisol 9 hr after challenge, Blood
Basic Attributes
- Class
- CHAL
- Type
- Laboratory
- First Released
- Version 2.52
- Last Updated
- Version 2.58 (MIN)
- Order vs. Observation
- Observation
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Κορτιζόλη^9 ώρες κατόπιν πρόκλησης XXX: Synonyms: SCnc Κορτιζόλη Πρόκληση |
es-ES | Spanish (Spain) | Cortisol^9 horas pos provocación XXX: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Cortisol ^9H después del desafío XXX: |
et-EE | Estonian (Estonia) | Kortisool^9 tundi pärast XXX manustamist: Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
fr-CA | French (Canada) | Cortisol^9 h post test de provocation XXX: |
fr-FR | French (France) | Cortisol T09h après épreuve: |
fr-BE | French (Belgium) | Cortisol^9 h post test de provocation XXX: |
it-IT | Italian (Italy) | Cortisolo^9h post XXX provocazione: Synonyms: 9 ore dopo XXX stimolo Concentrazione di Sostanza dopo XXX provocazione Plasma Punto nel tempo (episodio) Siero Siero o Plasma Stimolo Test di provocazione |
nl-NL | Dutch (Netherlands) | cortisol^9 uur na XXX belasting: Synonyms: 9U na XXX belasting |
ru-RU | Russian (Russian Federation) | Кортизол^9 часов после XXX пробы: Synonyms: Количественный Молярность; |
tr-TR | Turkish (Turkey) | Kortizol^9Sa snr XXX girişimi: |
zh-CN | Chinese (China) | 皮质醇^在XXX刺激之后9小时: Synonyms: 17-羟皮质甾酮; |
Example Units
Unit | Source |
---|---|
nmol/L | Example UCUM Units |
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