Version 2.74

Term Description

Specific antibodies for IgM are present during the acute phase of the Toscana Virus infection, while the presence of specific IgG antibodies in the absence of IgM indicates a previous infection. Cross reactions cannot be excluded with other correlated serotypes of Phlebovirus such as Sicily and Naples. This term was created for, but not limited in use to, the submitter's Diesse ENZYWELL TOSCANA VIRUS IgG/IgM test kit.
Source: Regenstrief LOINC

Part Descriptions

LP190786-6   Toscana virus
Toscana virus (TOSV) was identified in 1971 in central Italy from sandflies Phlebotomus perniciosus and Phlebotomus perfiliewi [PMID: 24175218]. TOSV belongs to the family Phenuiviridae, genus Phlebovirus [NCBI Taxonomy: 11590)]. TOSV is a serotype of the species Sandfly fever Naples virus [PMID: 24175218]. TOSV is the only neurotropic sandfly phlebovirus typically causing meningitis and encephalitis. Additional neuroinvasive manifestations such as Guillain-Barré syndrome, hydrocephalus, myositis, fasciitis, polymyeloradiculopathy, deafness, and facial paralysis, have been reported. Toscana virus broadly circulates in in European Mediterranean basin and Northern Africa [PMID: 32878929]. Source: Regenstrief LOINC

LP190786-6   Toscana virus
The Toscana virus (TOSV) belongs to the Bunyaviridae family whose genome is made of three negative single-stranded RNA segments. There are two genotypes of TOSV: A, found mainly in Italy, and B, occurring mainly in Spain. The distribution of the two genotypes may indicate the involvement of different vectors. Infection by TOSV is most prevalent in Italy and Spain in the summer months, though the geographical region where TOSV is expanding includes other countries in the Mediterranean basin. TOSV is transmitted to humans by the Phlebotomus species of sandflies. Though the animal reservoir has not been identified, TOSV has been isolated from the brain of a bat, which raises the question of it possibly being a host to the virus. TOSV causes aseptic meningitis in 95% of the people it infects, meningoencephalitis in 4.5% of those infected, and an influenza-like illness in the remaining .5% who are infected. Recently, unusual symptoms associated with TOSV have included ischemic complications and hydrocephalus. TOSV is emerging as an important pathogen as its distribution increases due to changes in the climate, globalization and habitat modification. Other than supportive therapy, there is no treatment for infection with TOSV.[PMID: 20517492] Source: Regenstrief LOINC

LP190787-4   Toscana virus Ab.IgM
The Toscana virus (TOSV) belongs to the Phlebovirus genus of the Bunyaviridae family, and is an arthropod-borne virus transmitted to humans by Phlebotomus spp sandflies. The Toscana virus infection is characterized by fever, strong headache, and meningitis, or meningoencephalitis. TOSV is the major cause of aseptic meningitis (95%) and meningoencephalitis (4.5%) and influenza-like illness during the summer season. Some unusual clinical manifestations due to TOSV with severe sequelae, such as ischemic complications and hydrocephalus, have been reported. TOSV represents an important emerging pathogen and it is being investigated in several countries on the Mediterranean basin, including Italy, France, Spain, Portugal and Cyprus. Phylogenetic analysis has distinguished two genotypes of TOSV, A and B. The first is circulating mainly in Italy and the second in Spain, indicating a different geographic distribution possibly related to the vector. There is no treatment for TOSV infection except for supportive therapy.[PMID: 20517492] Source: Regenstrief LOINC, PMID: 20517492

Fully-Specified Name

Component
Toscana virus Ab.IgM
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
IA

Additional Names

Short Name
TOSV IgM Ser Ql IA
Display Name
Toscana virus IgM IA Ql (S)
Consumer Name Alpha Get Info
Toscana virus IgM antibody, Blood

Example Answer List: LL2010-8

Source: Estonian Society of Laboratory Medicine
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Borderline LA4259-3

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: TOSV-AK IgM ql.
de-DE German (Germany) Toskana-Virus Ak.IgM:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Immunoassay
Synonyms: TOS; Sandmücken-Fieber; Toscana-Virus
es-ES Spanish (Spain) Virus Toscana IgM:PrThr:Punto temporal:Suero:Ord:IA
es-MX Spanish (Mexico) Ab.IgM del virus de Toscana:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
fr-FR French (France) Toscana virus Ac IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
it-IT Italian (Italy) Virus Toscana Ab.IgM:PrThr:Pt:Siero:Ord:IA
Synonyms: Anticorpi IgM anticorpo Immunoassay Microbiologia Presenza o Soglia Punto nel tempo (episodio) Siero
nl-NL Dutch (Netherlands) Toscana virus As.IgM:aanwezigheid:moment:serum:ordinaal:immunoassay
Synonyms: antistof; antilichaam IA
tr-TR Turkish (Turkey) Toscana virüs Ab.IgM:MevcEşik:Zmlı:Ser:Srl:İA
Synonyms: Ak Ak.IgM İmmünölçüm, immünoassay Mevcut
zh-CN Chinese (China) 托斯卡纳病毒 抗体.IgM:存在情况或阈值:时间点:血清:序数型:免疫测定法
Synonyms: Ab.IgM;IgM;抗体 IgM Ab;自身抗体 Toscana 病毒 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 M 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 时刻;随机;随意;瞬间

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