78209-4
CCND1 gene duplication [Interpretation] in Blood or Tissue by FISH Narrative
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Part Descriptions
LP36229-0 CCND1 gene
The CCND1 gene (cyclin D1) [HGNC Gene ID:1582] is located on chromosome 11q13. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] [NCBI Gene ID:595]
Source: National Center for Biotechnology Information (NCBI) Gene
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
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Source: Wikipedia, FISH
Fully-Specified Name
- Component
- CCND1 gene duplication
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nar
- Method
- FISH
Additional Names
- Short Name
- CCND1 gene Dp Bld/T FISH-Imp
- Display Name
- CCND1 gene dup FISH Nar (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- Interpretation of CCND1 gene duplication analysis test result, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.DELDUP
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.61
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gen CCND1 Duplicación: |
| es-MX | Spanish (Mexico) | Duplicación del gen CCND1: |
| fr-FR | French (France) | CCND1 gène duplication: |
| it-IT | Italian (Italy) | CCND1, gene, duplicazione: Synonyms: Delezione o duplicazione genica Gene CCND1 Ibridazione in situ fluorescente (FISH) Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | CCND1-gen duplicatie: Synonyms: CCND1 gen |
| tr-TR | Turkish (Turkey) | CCND1 geni dublikasyon: Synonyms: çiftleme |
| zh-CN | Chinese (China) | CCND1 基因 复制: Synonyms: B 细胞 CLL; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=78209-4
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