78210-2
ALK gene rearrangements [Interpretation] in Blood or Tissue by FISH Narrative
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Part Descriptions
LP189759-6 ALK gene rearrangements
The ALK gene (anaplastic lymphoma receptor tyrosine kinase) [HGNC Gene ID: 427] is located on chromosome 2p23. This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] [NCBI Gene ID: 238]
Source: National Center for Biotechnology Information (NCBI) Gene
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
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Source: Wikipedia, FISH
Fully-Specified Name
- Component
- ALK gene rearrangements
- Property
- Imp
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nar
- Method
- FISH
Additional Names
- Short Name
- ALK rearrange Bld/T FISH-Imp
- Display Name
- ALK rearrangements FISH Nar (Bld/Tiss) [Interp]
- Consumer Name Alpha Get Info
- Interpretation of ALK rearrangements test result, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.REARRANGE
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.65
- Change Reason
- Changed Order_Obs from 'Observation Only' to 'Both' to fit current order use cases.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | reordenamientos del gen ALK: |
| es-MX | Spanish (Mexico) | Reordenamientos del gen ALK: |
| fr-FR | French (France) | ALK gène réarrangements: |
| it-IT | Italian (Italy) | Riarrangiamenti del gene ALK: Synonyms: Gene ALK Ibridazione in situ fluorescente (FISH) Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | ALK-genherschikking: Synonyms: ALK-gentranslocaties |
| tr-TR | Turkish (Turkey) | ALK geni yeniden düzenleme: |
| zh-CN | Chinese (China) | ALK 基因重排: Synonyms: ALK 基因重排（重组） Fluorescent in situ hybridization; |
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