78216-9

TRA+TRD gene rearrangements [Presence] in Blood or Tissue by FISH

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Term Description

This term was created for, but is not limited in use to, the LSI TRA/D (TCR alpha/delta) Dual Color Break Apart Probe kit, which is intended for use in identifying rearrangements involving the T-cell receptor alpha/delta locus at chromosome region 14q11.2.
Source: Regenstrief LOINC

Part Descriptions

LP189756-2   TRA+TRD gene rearrangements
Chromosome region 14q11 is the site of the T-cell receptor (TCR) gene alpha/delta locus. Chromosomal translocations involving various TCR loci are a hallmark of T-cell acute lymphoblastic leukemias (T-ALLs), and rearrangements specifically involving the TCR alpha/delta locus are one of the more common patterns. T-ALLs occur in both adult and pediatric patients and account for 15-25% of ALLs in both patient populations. PMID: 22948044 Source: Regenstrief LOINC, PMID: 22948044

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component

TRA+TRD gene rearrangements

Property

PrThr

Time

Pt

System

Bld/Tiss

Scale

Ord

Method

FISH

Additional Names

Short Name

TRA+TRD rearrange Bld/T Ql FISH

Display Name

TRA+TRD rearrangements FISH Ql (Bld/Tiss)

Consumer Name Alpha Get Info

TRA+TRD rearrangements, Blood or tissue specimen

Example Answer List: LL744-4

Basic Attributes

Class

MOLPATH.REARRANGE

Type

Laboratory

First Released

Version 2.54

Last Updated

Version 2.61

Change Reason

The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Language Variants Get Info

Related Names

• Blood
• Fluorescent in situ hybridization
• Genetics
• Heredity
• Heritable
• Inherited
• Molecular pathology
• MOLPATH
• MOLPATH.REARRANGEMENTS
• Ordinal
• Point in time
• PR
• QL
• Qual
• Qualitative
• Random
• Rearr
• Rearrangement
• Screen
• Tissue
• Tissue, unspecified
• TRA+TRD rearrange
• WB
• Whole blood
• Whole blood or Tissue

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78216-9

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.