78222-7

MYC gene rearrangements [Interpretation] in Blood or Tissue by FISH Narrative

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Part Descriptions

LP19780-3 MYC gene rearrangements
The MYC gene (v-myc avian myelocytomatosis viral oncogene homolog) [HGNC Gene ID:7553] is located on chromosome 8q24.21. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:4609] Source: National Center for Biotechnology Information (NCBI) Gene

LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , FISH

Fully-Specified Name

Component: MYC gene rearrangements
Property: Imp
Time: Pt
System: Bld/Tiss
Scale: Nar
Method: FISH

Additional Names

Long Common Name: MYC gene rearrangements [Interpretation] in Blood or Tissue by FISH Narrative
Short Name: MYC gene Rear Bld/T FISH-Imp
Display Name: MYC gene rearrangements FISH Nar (Bld/Tiss) [Interp]
Consumer Name Alpha Get Info: Interpretation of MYC gene rearrangements test result, Blood or tissue specimen

Basic Attributes

Class: MOLPATH.REARRANGE
Type: Laboratory
First Released: Version 2.54
Last Updated: Version 2.61 (MIN)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	Γονιδιακές αναδιατάξεις MYC:Imp:Pt:Αίμα/Ιστός:Nar:Φθορίζουσα υβριδοποίηση in situ Synonyms: Imp Γονιδιακές αναδιατάξεις MYC Γονίδιο Γονίδιο MYC
es-ES	Spanish (Spain)	Reordenamientos del gen MYC:Impresión/interpretación del estudio:Punto temporal:Sangre o tejido:Narrativo:Hibridación in situ fluoresente (FISH)
es-MX	Spanish (Mexico)	Reordenamientos del gen MYC:Impresión / interpretación del estudio:Punto temporal:Sangre o tejido:Narrativo:Hibridación fluorescente in situ (FISH)
fr-FR	French (France)	MYC gène réarrangements:Interprétation:Ponctuel:Sang/Tissu:Résultat textuel:FISH
it-IT	Italian (Italy)	MYC, riarrangiamenti gene:Imp:Pt:Sangue/Tess:Nar:FISH Synonyms: Gene MYC Ibridazione in situ fluorescente (FISH) Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Riarrangiamenti gene MYC Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL	Dutch (Netherlands)	MYC genherschikking:interpretatie:moment:bloed of weefsel:tekstueel:FISH Synonyms: MYC gen MYC gentranslocatie
tr-TR	Turkish (Turkey)	MYC geni yeniden düzenlemeler:İzlnm:Zmlı:Kan/Dk:Öykü:FISH
zh-CN	Chinese (China)	MYC 基因重排:印象:时间点:全血/组织:叙述型:FISH Synonyms: Burkitt 淋巴瘤 Burkitts 淋巴瘤 c-MYC Fluorescent in situ hybridization;荧光原位杂交 MYC 原癌基因 MYC 基因重排（重组） v-myc myelocytomatosis viral oncogene homolog (avian);MYC;MRTL;bHLHe39;c-Myc;avian myelocytomatosis viral oncogene homolog;class E basic helix-loop-helix protein 39;myc proto-oncogene protein;myc-related translation/localization regulatory factor;proto-on v-myc 骨髓细胞瘤病毒原癌基因同源基因 v-myc 骨髓细胞瘤病毒原癌基因同源基因（v-myc myelocytomatosis viral oncogene homolog） v-myc 髓细胞瘤病毒原癌基因同源基因 v-myc 髓细胞组织增生病毒原癌基因同源基因 v-myc 髓细胞组织增生症病毒原癌基因同源基因与骨髓细胞瘤病毒同源的原癌基因与骨髓细胞瘤病毒同源的原癌基因（Protooncogene homologous to myelocytomatosis virus）与髓细胞瘤病毒同源的原癌基因与髓细胞组织增生病毒同源的原癌基因与髓细胞组织增生症病毒同源的原癌基因伯基特氏淋巴瘤伯基特淋巴瘤全血或组织;血液/组织;血液或组织分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排分子病理学;分子病理学试验印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片血;血液遗传基因;遗传因子;吉恩;生物基因骨髓细胞瘤病毒同源原癌基因髓细胞瘤病毒同源原癌基因髓细胞组织增生病毒同源原癌基因髓细胞组织增生症病毒同源原癌基因

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