78236-7

Cells.IGH gene rearrangements/Cells counted in Blood or Tissue by FISH

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Part Descriptions

LP190806-2 Cells.IGH gene rearrangements
The IGH gene (immunoglobulin heavy locus) [HGNC Gene ID: 5477] is located on chromosome 14q32.33. Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Oct 2013] [NCBI Gene ID: 3492] Source: National Center for Biotechnology Information (NCBI) Gene

LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name: Cells.IGH gene rearrangements/Cells counted:NFr:Pt:Bld/Tiss:Qn:FISH
Long Common Name: Cells.IGH gene rearrangements/Cells counted in Blood or Tissue by FISH
Short Name: Cells.IGH rear/Cells cnt NFr Bld/T FISH
Display Name: Cells.IGH rearrangements/Cells counted FISH (Bld/Tiss)
Consumer Name Alpha Get Info: Cells.IGH Rearrangements/Cells Counted, Blood or tissue specimen

Part Model Get Info

Component
Cells.IGH gene rearrangements/Cells counted
LP285672-4
- Analyte
  Cells.IGH gene rearrangements/Cells counted
  LP285672-4
  - Component Numerator
    Cells.IGH gene rearrangements
    LP190806-2
    - Component Numerator Core
      Cells.IGH gene rearrangements
      LP190806-2
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Cells counted
    LP190810-4
    - Component Denominator Core
      Cells counted
      LP190810-4
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NFr
LP6838-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld/Tiss
LP7061-7
- System Core
  Bld/Tiss
  LP7061-7
- Super System
  NULL
Scale
Qn
LP7753-9
Method
FISH
LP62864-1

Basic Attributes

Class: MOLPATH.REARRANGE
Type: Laboratory
First Released: Version 2.54
Last Updated: Version 2.61 (MIN)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Buňky.gen IGH přestavba/buňky spočítané:Početní podíl:Časový bod:Krev/tkáň:Kvantitativní:Fluorescenční in situ hybridizace (FISH)
el-GR	Greek (Greece)	Κύτταρα.Γονιδιακές αναδιατάξεις IGH/Μετρηθέντα κύτταρα:NFr:Pt:Αίμα/Ιστός:Qn:Φθορίζουσα υβριδοποίηση in situ Synonyms: MOLPATH MOLPATH.REARRANGE NFr Pt Qn Αίμα Αίμα/Ιστός Γονιδιακές αναδιατάξεις IGH Γονίδιο Ιστός Κύτταρα Κύτταρα.Γονιδιακές αναδιατάξεις IGH Μετρηθέντα κύτταρα Φθορίζουσα υβριδοποίηση in situ
es-ES	Spanish (Spain)	Reordenamientos del gen IGH/Contaje celular:Fracción numérica:Punto temporal:Sangre o tejido:Qn:Hibridación in situ fluoresente (FISH) Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Cells.IGH genes reordenamientos / Células contadas:Fracción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FR	French (France)	IGH gène réarrangements/cellules comptées:Fraction de nombres:Ponctuel:Sang/Tissu:Numérique:FISH
it-IT	Italian (Italy)	Cellule.riarrangiamenti gene IGH/Cellule contate:NFr:Pt:Sangue/Tess:Qn:FISH Synonyms: Frazione numerica Ibridazione in situ fluorescente (FISH) Patologia molecolare Punto nel tempo (episodio) Riarrangiamenti del gene della catena pesante dell Riarrangiamenti gene codificante per la catena pes Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL	Dutch (Netherlands)	cellen.IGH-genherschikking/getelde cellen:getalsfractie:moment:bloed of weefsel:kwantitatief:FISH Synonyms: cellen.IGH gen translocaties IGH-gentranslocatie
pl-PL	Polish (Poland)	Komórki.IGH gen rearanżacje/zliczone komórki:frakcja liczbowa:punkt w czasie:krew lub tkanka:ilościowy:FISH Synonyms: fluorescencyjna hybrydyzacja in situ IGH gen Komórki z rearanżacjami genu IGH Rearanżacje genu IGH
tr-TR	Turkish (Turkey)	Hücreler.IGH geni yeniden düzenleme/Hücreler sayılan:SayFr:Zmlı:Kan/Dk:Kant:FISH
zh-CN	Chinese (China)	细胞.IGH 基因重排/已计数的细胞:计数型分数:时间点:全血/组织:定量型:FISH Synonyms: Fluorescent in situ hybridization;荧光原位杂交 IGH 基因重排（重组）全血或组织;血液/组织;血液或组织分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排分子病理学;分子病理学试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺所计数的细胞;计数细胞;所计数细胞;已计数细胞所计数细胞;已计数过细胞;已计数细胞;已计过数细胞数量型分数;数量或计数型分数;数量型分数或计数型分数时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片细胞.IGH 基因重排（重组）细胞含量;细胞性;细胞性质;细胞构成;细胞类血;血液遗传基因;遗传因子;吉恩;生物基因

Example Units

Unit	Source
%	Example UCUM Units

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.