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Part Description

LP200267-5   Trimethyllysine
Trimethyllysine (N6,N6,N6-Trimethyl-L-lysine) is a methylated derivative of the amino acid lysine. It is a component of histone proteins, a precursor of carnitine and a coenzyme of fatty acid oxidation. N6,N6,N6-Trimethyl-L-lysine residues are found in a number of proteins and are generated by the action of S-adenosyl-L-methionine on exposed lysine residues. When trimethyllysine is released from cognate proteins via proteolysis, it serves as a precursor for carnitine biosynthesis. Mitochondrial 6-N-trimethyllysine dioxygenase converts 6-N-trimethyllysine to 3-hydroxy-6-N-trimethyllysine as the first step for carnitine biosynthesis. Because the subsequent carnitine biosynthesis enzymes are cytosolic, 3-hydroxy-6-N-trimethyllysine must be transported out of the mitochondria by a putative mitochondrial 6-N-trimethyllysine/3-hydroxy-6-N-trimethyllysine transporter system. Plasma -N-trimethyllysine concentrations are significantly lower in systemic carnitine deficiency patients compared to normal individuals, but no significant difference in urinary -N-trimethyllysine excretion is seen between the two groups.[HMDB ID: HMDB01325] Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database

LOINC Names Get Info

Fully-Specified Name
Trimethyllysine:SCnc:Pt:Ser/Plas:Qn:
Long Common Name
Trimethyllysine [Moles/volume] in Serum or Plasma
Short Name
TML SerPl-sCnc
Display Name
Trimethyllysine [Moles/Vol]
Consumer Name Alpha Get Info
Trimethyllysine, Blood

Part Model Get Info

  • Component
    Trimethyllysine
    LP200267-5
    • Analyte
      Trimethyllysine
      LP200267-5
      • Component Numerator
        Trimethyllysine
        LP200267-5
        • Component Numerator Core
          Trimethyllysine
          LP200267-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SCnc
    LP6860-3
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.54 (ADD)
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
79285-3Carnitine biosynthesis intermediates panel - Serum or Plasma

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Trimethyllysin:Látková koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
el-GRGreek (Greece)Τριμεθυλολυσίνη:SCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: CHEM Pt Qn SCnc Ορός Ορός/Πλάσμα Πλάσμα Τριμεθυλολυσίνη
es-ESSpanish (Spain)Trimetil lisina:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Trimetilisina:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
fr-FRFrench (France)Triméthyllysine:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-ITItalian (Italy)Trimetil-lisina:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Sostanza Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NLDutch (Netherlands)trimethyllysine:mol/volume:moment:serum of plasma:kwantitatief:
pl-PLPolish (Poland)Trimetylolizyna:stężenie molowe:punkt w czasie:surowica lub osocze:ilościowy:
tr-TRTurkish (Turkey)Trimetillizin:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CNChinese (China)三甲基赖氨酸:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

UnitSource
umol/LExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79328-1