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Part Descriptions

LP200267-5   Trimethyllysine
Trimethyllysine (N6,N6,N6-Trimethyl-L-lysine) is a methylated derivative of the amino acid lysine. It is a component of histone proteins, a precursor of carnitine and a coenzyme of fatty acid oxidation. N6,N6,N6-Trimethyl-L-lysine residues are found in a number of proteins and are generated by the action of S-adenosyl-L-methionine on exposed lysine residues. When trimethyllysine is released from cognate proteins via proteolysis, it serves as a precursor for carnitine biosynthesis. Mitochondrial 6-N-trimethyllysine dioxygenase converts 6-N-trimethyllysine to 3-hydroxy-6-N-trimethyllysine as the first step for carnitine biosynthesis. Because the subsequent carnitine biosynthesis enzymes are cytosolic, 3-hydroxy-6-N-trimethyllysine must be transported out of the mitochondria by a putative mitochondrial 6-N-trimethyllysine/3-hydroxy-6-N-trimethyllysine transporter system. Plasma -N-trimethyllysine concentrations are significantly lower in systemic carnitine deficiency patients compared to normal individuals, but no significant difference in urinary -N-trimethyllysine excretion is seen between the two groups.[HMDB ID: HMDB01325] Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

LOINC Names Get Info

Fully-Specified Name
Trimethyllysine/Creatinine:SRto:Pt:Urine:Qn:
Long Common Name
Trimethyllysine/Creatinine [Molar ratio] in Urine
Short Name
TML/Creat Ur-sRto
Display Name
Trimethyllysine/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info
Trimethyllysine/Creatinine, Urine

Part Model Get Info

  • Component
    Trimethyllysine/Creatinine
    LP287311-7
    • Analyte
      Trimethyllysine/Creatinine
      LP287311-7
      • Component Numerator
        Trimethyllysine
        LP200267-5
        • Component Numerator Core
          Trimethyllysine
          LP200267-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Creatinine
        LP32035-5
        • Component Denominator Core
          Creatinine
          LP32035-5
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SRto
    LP6868-6
  • Time
    Pt
    LP6960-1
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.54 (ADD)
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
79287-9Carnitine biosynthesis intermediates panel - Urine

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Trimethyllysin/kreatinin:Látkový poměr:Časový bod:Moč:Kvantitativní:
el-GRGreek (Greece)Τριμεθυλολυσίνη/Κρεατινίνη:SRto:Pt:Ούρα:Qn:
Synonyms: CHEM Pt Qn SRto Κρεατινίνη Ούρα Τριμεθυλολυσίνη
es-ESSpanish (Spain)Trimetil lisina/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Trimetilisina / Creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-FRFrench (France)Triméthyllysine/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
it-ITItalian (Italy)Trimetil-lisina/Creatinina:Srto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NLDutch (Netherlands)trimethyllysine/creatinine:molaire verhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
pl-PLPolish (Poland)Trimetylolizyna/kreatynina:współczynnik molowy:punkt w czasie:mocz:ilościowy:
tr-TRTurkish (Turkey)Trimetillizin/Kreatinin:SOrn:Zmlı:İdrar:Kant:
Synonyms: SubsOranı
zh-CNChinese (China)三甲基赖氨酸/肌酐:物质的量比率:时间点:尿液:定量型:
Synonyms: CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 时刻;随机;随意;瞬间 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 肌酸内酰胺

Example Units

UnitSource
umol/mol{creat}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79331-5