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Part Description

LP15841-7   Purine nucleoside phosphorylase
Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that, together with adenosine deaminase (ADA), serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in ADA lead to an accumulation of (d)ATP, which inhibits ribonucleotide reductase, leading to a deficiency in (d)CTPs and (d)TTPs, which, in turn, induces apoptosis in T-lymphocytes and B-lymphocytes, leading to severe combined immunodeficiency (SCID).

PNP-deficient patients will have an immunodeficiency problem. It affects only T-cells; B-cells are unaffected by the deficiency. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Purine nucleoside phosphorylase:CSub:Pt:RBC:Qn:
Long Common Name
Purine nucleoside phosphorylase [Enzymatic activity/substance] in Red Blood Cells
Short Name
PNP cSub RBC
Display Name
Purine nucleoside phosphorylase (RBC) [Catalytic activity/Moles]
Consumer Name Alpha Get Info
Purine nucleoside phosphorylase, Red blood cells

Part Model Get Info

  • Component
    Purine nucleoside phosphorylase
    LP15841-7
    • Analyte
      Purine nucleoside phosphorylase
      LP15841-7
      • Component Numerator
        Purine nucleoside phosphorylase
        LP15841-7
        • Component Numerator Core
          Purine nucleoside phosphorylase
          LP15841-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    CSub
    LP149700-9
  • Time
    Pt
    LP6960-1
  • System
    RBC
    LP7536-8
    • System Core
      RBC
      LP7536-8
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.54 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Purin-nukleosidfosforyláza:Poměr katalytická aktivita/látkové množství:Časový bod:Erytrocyty:Kvantitativní:
el-GRGreek (Greece)Φωσφορυλάση πουρινικών νουκλεοσιδίων:CSub:Pt:Ερυθρά αιμοσφαίρια:Qn:
Synonyms: CHEM CSub Pt Qn Ερυθρά αιμοσφαίρια Πουρίνη Φωσφορυλάση Φωσφορυλάση πουρινικών νουκλεοσιδίων
es-ESSpanish (Spain)Purin nucleósido fosforilasa:CSub:Punto temporal:Glóbulos rojos:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Purina nucleósido fosforilasa:Sustancia catalítica:Punto temporal:Eritrocitos:Cuantitativo:
fr-FRFrench (France)Purine nucléoside phosphorylase:Substance catalytique:Ponctuel:Érythrocytes:Numérique:
it-ITItalian (Italy)Purina nucleoside fosforilasi:CSub:Pt:RBC:Qn:
Synonyms: Chimica Globuli rossi PNPasi Punto nel tempo (episodio) Sostanza catalitica
nl-NLDutch (Netherlands)purinenucleosidefosforylase:enzymatische activiteit/mol:moment:erytrocyten:kwantitatief:
Synonyms: rode bloedcellen
pl-PLPolish (Poland)Fosforylaza nukleozydów purynowych:substancja katalityczna:punkt w czasie:krwinki czerwone:ilościowy:
ru-RURussian (Russian Federation)Пуриновых нуклеозидов фосфорилаза:КаталВещ:ТчкВрм:Эритроциты:Колич:
Synonyms: Каталитическое вещество;Катализатор Количественный Точка во времени;Момент
tr-TRTurkish (Turkey)Pürin nukleozid fosforilaz:KtlSub:Zmlı:Eritrosit:Kant:
Synonyms: RBC
zh-CNChinese (China)嘌呤核苷酸磷酸化酶:单位物质的量相对型催化活性:时间点:红细胞:定量型:
Synonyms: Catalytic substance;Csub;酶相对浓度;单位摩尔相对型催化活性;单位克分子相对型催化活性;催化性物质;催化性化学物质 PNP RBC;RBCS;红血球;红血细胞;赤血球 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 四氮杂茚 时刻;随机;随意;瞬间

Example Units

UnitSource
mol/h/mol{Hb}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79466-9