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Part Description

LP15841-7   Purine nucleoside phosphorylase
Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that, together with adenosine deaminase (ADA), serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in ADA lead to an accumulation of (d)ATP, which inhibits ribonucleotide reductase, leading to a deficiency in (d)CTPs and (d)TTPs, which, in turn, induces apoptosis in T-lymphocytes and B-lymphocytes, leading to severe combined immunodeficiency (SCID).

PNP-deficient patients will have an immunodeficiency problem. It affects only T-cells; B-cells are unaffected by the deficiency. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Purine nucleoside phosphorylase:CCnc:Pt:Bld.dot:Qn:
Long Common Name
Purine nucleoside phosphorylase [Enzymatic activity/volume] in DBS
Short Name
PNP DBS-cCnc
Display Name
Purine nucleoside phosphorylase (DBS) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Purine nucleoside phosphorylase, Dried blood spot

Part Model Get Info

  • Component
    Purine nucleoside phosphorylase
    LP15841-7
    • Analyte
      Purine nucleoside phosphorylase
      LP15841-7
      • Component Numerator
        Purine nucleoside phosphorylase
        LP15841-7
        • Component Numerator Core
          Purine nucleoside phosphorylase
          LP15841-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    CCnc
    LP6789-4
  • Time
    Pt
    LP6960-1
  • System
    Bld.dot
    LP21304-8
    • System Core
      Bld.dot
      LP21304-8
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.61 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Purin-nukleosidfosforyláza:Katalytická koncentrace:Časový bod:Suchá krevní kapka (DBS):Kvantitativní:
el-GRGreek (Greece)Φωσφορυλάση πουρινικών νουκλεοσιδίων:CCnc:Pt:Bld.dot:Qn:
Synonyms: Bld.dot CCnc CHEM Pt Qn Αίμα Πουρίνη Φωσφορυλάση Φωσφορυλάση πουρινικών νουκλεοσιδίων
es-ESSpanish (Spain)Purin nucleósido fosforilasa:Concentración Catalítica:Punto temporal:gota de sangre (papel de filtro):Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Purina nucleósido fosforilasa:Concentración catalítica:Punto temporal:DBS:Cuantitativo:
et-EEEstonian (Estonia)Puriini nukleosiidi fosforülaas:CCnc:Pt:Vereplekk:Qn:
Synonyms: Juhuslik Kvantitatiivne Veri
fr-CAFrench (Canada)Purine-nucléoside phosphorylase:Concentration catalytique:Temps ponctuel:Sang sur papier filtre:Quantitatif:
fr-FRFrench (France)Purine nucléoside phosphorylase:Catalytique/Volume:Ponctuel:Sang buvard:Numérique:
fr-BEFrench (Belgium)Purine-nucléoside phosphorylase:Concentration catalytique:Temps ponctuel:Sang sur papier filtre:Quantitatif:
it-ITItalian (Italy)Purina nucleoside fosforilasi:CCnC:Pt:Sangue.su carta da filtro:Qn:
Synonyms: Chimica Concentrazione Catalitica PNPasi Punto nel tempo (episodio) Sangue Spot sangue secco
nl-NLDutch (Netherlands)purinenucleosidefosforylase:enzymatische activiteit/volume:moment:gedroogde bloedspot:kwantitatief:
pl-PLPolish (Poland)Fosforylaza nukleozydów purynowych:stężenie katalityczne:punkt w czasie:sucha kropla krwi:ilościowy:
ru-RURussian (Russian Federation)Пуриновых нуклеозидов фосфорилаза:КаталКонц:ТчкВрм:Кр.Сух.капл:Колич:
Synonyms: Каталитическая концентрация Количественный Кровь Кровь сухая капля Точка во времени;Момент
tr-TRTurkish (Turkey)Pürin nukleozid fosforilaz:KtlKons:Zmlı:Kan.nokta:Kant:
zh-CNChinese (China)嘌呤核苷酸磷酸化酶:催化浓度:时间点:全血.斑点:定量型:
Synonyms: PNP 催化浓度(单位体积);单位体积内酶的单位数 全血斑点(滤纸);滤纸;血液.斑点;血液斑点(滤纸) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 四氮杂茚 时刻;随机;随意;瞬间 血;血液

Example Units

UnitSource
nmol/h/mLExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79467-7