79594-8

Glycylproline/Creatinine [Molar ratio] in Urine

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Part Descriptions

LP201675-8   Glycylproline
Glycylproline is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. Prolidase deficiency is a rare autosomal recessive disease characterized by chronic ulcerative dermatitis, mental retardation, frequent infections and massive urinary excretion of iminodipeptides. The disease has been confirmed to be due to hereditary prolidase deficiency. It has been reported that the activity of the enzyme against glycylproline (Gly-Pro) is almost totally deficient in patients with prolidase deficiency, whereas the activity against other substrates is not so deficient. Some patients with prolidase deficiency have a marked urinary excretion of the iminodipeptide Glycylproline. The urine from patients with pressure sores contains significantly more Glycylproline than the urine from the control. PMID: 16009141 PMID: 7629169 PMID: 1536787 PMID: 10582130 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database ,

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , Creatinine

Fully-Specified Name

Component

Glycylproline/Creatinine

Property

SRto

Time

Pt

System

Urine

Scale

Qn

Method

Additional Names

Long Common Name

Glycylproline/Creatinine [Molar ratio] in Urine

Short Name

Gly-pro/Creat Ur-sRto

Display Name

Glycylproline/Creatinine (U) [Molar ratio]

Consumer Name Alpha Get Info

Glycylproline/Creatinine, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.54

Last Updated

Version 2.56 (MIN)

Change Reason

Changed Class from CHEM.ESOTERIC to CHEM and added Esoteric tag for more flexibility

Order vs. Observation

Observation

Language Variants Get Info

Related Names

• 1-(2-aminoacetyl)pyrrolidine-2-carboxylic acid
• 1-(Aminoacetyl)proline
• 1-Glycyl-L-proline
• 1-Glycylproline
• Chemistry
• CR
• Crea
• Creat
• Esoteric
• Glycyl-L-proline
• Gly-pro
• N-glycylproline
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Scrto
• Substance concentration ratio
• Substance ratio
• UA
• UCr
• UR
• Urn

Example Units

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