LP201675-8
Glycylproline
Active
Description
Glycylproline is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. Prolidase deficiency is a rare autosomal recessive disease characterized by chronic ulcerative dermatitis, mental retardation, frequent infections and massive urinary excretion of iminodipeptides. The disease has been confirmed to be due to hereditary prolidase deficiency. It has been reported that the activity of the enzyme against glycylproline (Gly-Pro) is almost totally deficient in patients with prolidase deficiency, whereas the activity against other substrates is not so deficient. Some patients with prolidase deficiency have a marked urinary excretion of the iminodipeptide Glycylproline. The urine from patients with pressure sores contains significantly more Glycylproline than the urine from the control. PMID: 16009141 PMID: 7629169 PMID: 1536787 PMID: 10582130 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database ,
Basic Part Properties
- Part Name
- Glycylproline
- Part Display Name
- Glycylproline
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2015-10-22
- Construct for LOINC Short Name
- Gly-pro
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 甘氨酰脯氨酸 Synonyms: 甘氨酰基脯氨酸 |
| tr-TR | Turkish (Turkey) | Glisilprolin |
| es-ES | Spanish (Spain) | Glicilprolina |
| it-IT | Italian (Italy) | Glicile-proline |
| nl-NL | Dutch (Netherlands) | glycylproline |
| el-GR | Greek (Greece) | Γλυκυλ-προλίνη Synonyms: Γλυκυλ-προλίνη |
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