Version 2.80

Part Descriptions

LP201688-1   N6-Acetyl-L-lysine
N-acetyl-lysine is an acetylated amino acid. Post-translational lysine-acetylation is one of two major modifications of lysine residues in various proteins. Acetylation of specific lysine residues in the N-terminal domains of core histones is a biochemical marker of active genes. Acetylation is now known to play a major role in eukaryotic transcription. Specifically, acetyltransferase enzymes that act on particular lysine side chains of histones and other proteins are intimately involved in transcriptional activation. By modifying chromatin proteins and transcription-related factors, these acetylases are believed to regulate the transcription of many genes. The best-characterized mechanism is acetylation, catalyzed by histone acetyltransferase (HAT) enzymes. HATs function enzymatically by transferring an acetyl group from acetyl-coenzyme A (acetyl-CoA) to the -amino group of certain lysine side chains within a histone's basic N-terminal tail region. Within a histone octamer, these regions extend out from the associated globular domains, and in the context of a nucleosome, they are believed to bind the DNA through charge interactions (positively charged histone tails associated with negatively charged DNA) or mediate interactions between nucleosomes. Lysine acetylation, which neutralizes part of a tail region's positive charge, is postulated to weaken histone-DNA or nucleosome-nucleosome interactions and/or signal a conformational change, thereby destabilizing nucleosome structure or arrangement and giving other nuclear factors, such as the transcription complex, more access to a genetic locus. In agreement with this is the fact that acetylated chromatin has long been associated with states of transcriptional activation. Specific recognition of N-acetyl-lysine is a conserved function of all bromodomains found in different proteins, recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization. PMID: 9169194 PMID: 10827952 PMID: 17340003 PMID: 16247734 PMID: 9478947 PMID: 10839822 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database ,

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database , Creatinine

Fully-Specified Name

Component
N6-Acetyl-L-lysine/Creatinine
Property
SRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Long Common Name
N6-Acetyl-L-lysine/Creatinine [Molar ratio] in Urine
Short Name
N6-Ac-L-lys/Creat Ur-sRto
Display Name
N6-Acetyl-L-lysine/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info
N6-Acetyl-L-lysine/Creatinine, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.56 (MIN)
Change Reason
Changed Class from CHEM.ESOTERIC to CHEM and added Esoteric tag for more flexibility
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Ν6-ακετυλο-L-λυσίνη/Κρεατινίνη:SRto:Pt:Ούρα:Qn:
Synonyms: SRto Κρεατινίνη Λυσίνη Ν6-ακετυλο-L-λυσίνη
es-MX Spanish (Mexico) N6-acetil-L-lisina / creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
es-ES Spanish (Spain) N6-Acetil-L-lisina/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
fr-FR French (France) N6-acétyl-L-lysine/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
it-IT Italian (Italy) N6-Acetil-L-lisina/Creatinina:Srto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NL Dutch (Netherlands) N6-acetyl-L-lysine/creatinine:molaire verhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
tr-TR Turkish (Turkey) N6-Astil-L-lizin/Kreatinin:SOrn:Zmlı:İdrar:Kant:
Synonyms: SubsOranı
zh-CN Chinese (China) N6-乙酰-L-赖氨酸/肌酐:物质的量比率:时间点:尿液:定量型:
Synonyms: 2,6-二氨基已酸;Lys;氨基已氨酸;溶细胞素 CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 N6-乙酰基-L-赖氨酸 UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 左 左侧 左侧（Left，L） 时刻;随机;随意;瞬间 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 肌酸内酰胺

Example Units

Unit Source
umol/mmol{creat} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79634-2