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Part Descriptions

LP201690-7   Saccharopine
Saccharopine is an intermediate in the degradation of lysine, formed by condensation of lysine and alpha-ketoglutarate. The saccharopine pathway is the main route for lysine degradation in mammal and its first two reactions are catalyzed by enzymatic activities known as lysine-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH), which reside on a single bifunctional polypeptide (EC EC 1.5.1.8, LOR/SDH). The reactions involved by saccharopine dehydrogenases have a very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH. LOR/SDH has been detected in a number of mammalian tissues, mainly in the liver and kidney, contributing not only to the general nitrogen balance in the organism but also to the controlled conversion of lysine into ketone bodies. A tetrameric form has also been observed in human liver and placenta. LOR activity has also been detected in brain mitochondria during embryonic development, and this opens the question of whether the degradation of lysine has any functional significance during brain development and puts a new focus on the nutritional requirements for lysine in gestation and infancy. Finally, LOR and/or SDH deficiencies seem to be involved in a human autosomic genetic disorder known as familial hyperlysinemia, which is characterized by serious defects in the functioning of the nervous system, and characterized by deficiency in lysine-ketoglutarate reductase, saccharopine dehydrogenase, and saccharopine oxidoreductase activities. Saccharopinuria (high amounts of saccharopine in the urine) and saccharopinemia (an excess of saccharopine in the blood) are conditions present in some inherited disorders of lysine degradation. PMID: 463877 PMID: 10567240 PMID: 10772957 PMID: 4809305 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database,

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

LOINC Names Get Info

Fully-Specified Name
Saccharopine/Creatinine:SRto:Pt:Urine:Qn:
Long Common Name
Saccharopine/Creatinine [Molar ratio] in Urine
Short Name
Saccharopine/Creat Ur-sRto
Display Name
Saccharopine/Creatinine (U) [Molar ratio]
Consumer Name Alpha Get Info
Saccharopine/Creatinine, Urine

Part Model Get Info

  • Component
    Saccharopine/Creatinine
    LP286999-0
    • Analyte
      Saccharopine/Creatinine
      LP286999-0
      • Component Numerator
        Saccharopine
        LP201690-7
        • Component Numerator Core
          Saccharopine
          LP201690-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Creatinine
        LP32035-5
        • Component Denominator Core
          Creatinine
          LP32035-5
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SRto
    LP6868-6
  • Time
    Pt
    LP6960-1
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.56 (MIN)
Change Reason
Changed Class from CHEM.ESOTERIC to CHEM and added Esoteric tag for more flexibility
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Sacharopin/kreatinin:Látkový poměr:Časový bod:Moč:Kvantitativní:
el-GRGreek (Greece)Σακχαροπίνη/Κρεατινίνη:SRto:Pt:Ούρα:Qn:
Synonyms: CHEM Pt Qn SRto Κρεατινίνη Ούρα Σακχαροπίνη
es-ESSpanish (Spain)Sacaropina/Creatinina:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Sacaropina / Creatinina:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-FRFrench (France)Saccharopine/créatinine:Moles ratio:Ponctuel:Urine:Numérique:
it-ITItalian (Italy)Saccaropina/Creatinina:Srto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza
nl-NLDutch (Netherlands)saccharopine/creatinine:molaire verhouding:moment:urine:kwantitatief:
Synonyms: kreatinine
pl-PLPolish (Poland)Sacharopina/kreatynina:współczynnik molowy:punkt w czasie:mocz:ilościowy:
tr-TRTurkish (Turkey)Sakkaropin/Kreatinin:SOrn:Zmlı:İdrar:Kant:
Synonyms: SubsOranı
zh-CNChinese (China)酵母氨酸/肌酐:物质的量比率:时间点:尿液:定量型:
Synonyms: CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 尿液肌酐 尿液肌酸酐 尿肌酸酐 时刻;随机;随意;瞬间 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 肌酸内酰胺 酵母胺酸

Example Units

UnitSource
umol/mmol{creat}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79640-9