79711-8
HLA-B*58:01 [Presence] in Blood or Tissue
Active
Part Description
LP203037-9 HLA-B*58:01
The human leukocyte antigen B (HLA-B; [HGNC Gene ID: 4932]) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. Allopurinol specifically interacts with HLA-B*58:01 and alters the repertoire of self-peptides that are presented to T lymphocytes, which activates an immune reaction known as severe cutaneous adverse reactions (SCAR), including drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. PMID: 23232549 See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- HLA-B*58:01
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
Additional Names
- Short Name
- HLA-B*58:01 Bld/T Ql
- Display Name
- HLA-B*58:01 Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- HLA-B*58:01, Blood or tissue specimen
Preferred Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 15193
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-B*58: |
es-MX | Spanish (Mexico) | HLA-B * 58: |
fr-FR | French (France) | HLA-B*58: |
it-IT | Italian (Italy) | HLA-B*58: Synonyms: Farmacogenomica Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
nl-NL | Dutch (Netherlands) | HLA-B*58: |
tr-TR | Turkish (Turkey) | HLA-B*58: Synonyms: Mevcut |
zh-CN | Chinese (China) | HLA-B*58: Synonyms: B 型 HLA 抗原; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=79711-8
Third Party Copyright
This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.
This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.
Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright