LOINC
Version 2.67

79711-8HLA-B*58:01 [Presence] in Blood or TissueActive

Part Description

LP203037-9   HLA-B*58:01
The human leukocyte antigen B (HLA-B; [HGNC Gene ID: 4932]) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. Allopurinol specifically interacts with HLA-B*58:01 and alters the repertoire of self-peptides that are presented to T lymphocytes, which activates an immune reaction known as severe cutaneous adverse reactions (SCAR), including drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. [PMID: 23232549] See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component
HLA-B*58:01
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method

Additional Names

Short Name
HLA-B*58:01 Bld/T Ql
Display Name
HLA-B*58:01 Ql (Bld/Tiss)

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Preferred Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
HLA-B*58:01:存在情况或阈值:时间点:全血/组织:序数型:
nl-NLDutch (NETHERLANDS)
HLA-B*58:01:aanwezigheid:moment:bloed of weefsel:ordinaal:
fr-FRFrench (FRANCE)
HLA-B*58:01:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:
it-ITItalian (ITALY)
HLA-B*58:01:PrThr:Pt:Sangue/Tess:Ord:
es-ESSpanish (SPAIN)
HLA-B*58:01:PrThr:Punto temporal:Sangre o tejido:Ord:
tr-TRTurkish (TURKEY)
HLA-B*58:01:MevcEşik:Zmlı:Kan/Dk:Srl:

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79711-8