Version 2.78

Term Description

The CYP3A5 gene product metabolic activity interpretation is determined by the reporting lab and returned with the structured test results. The Preferred Answer list associated with this term is based on the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for reporting CYP3A5 gene product metabolic activity (phenotype), which apply to both genetic and enzymatic assays (this LOINC term represents a genetic assay). This specific interpretation would be considered a separate observation made by the lab in addition to the primary reported results (e.g., genotype or measured activity level) and it could be included with other assay-specific observations, which would ideally support the interpretation value. [https://cpicpgx.org/resources.html]
Source: Regenstrief LOINC

Part Description

LP202922-3   CYP3A5 gene product metabolic activity interpretation
Cytochrome P450-3A5 (CYP3A5; [HGNC Gene ID: 2638]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism many drugs in current clinical use. Genetic variations in CYP3A5 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP3A5 and selection of alternative dosing or agents may be necessary in individuals with specific CYP3A5 genetic variations. PMID: 25801146 See https://www.pharmgkb.org/gene/PA131 for more information and dosing guidelines for drugs impacted by CYP3A5 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component
CYP3A5 gene product metabolic activity interpretation
Property
Imp
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
Molgen

Additional Names

Short Name
CYP3A5 gene prod met act imp Bld/T-Imp
Display Name
CYP3A5 gene product metabolic activity interpretation Molgen Ql (Bld/Tiss) [Interp]
Consumer Name Alpha Get Info
CYP3A5 gene product metabolic activity interpretation, Blood or tissue specimen

Preferred Answer List: LL3856-3

Source: Clinical Pharmacogenetics Implementation Consortium
Answer Code Score Answer ID
Ultrarapid metabolizer LA10315-2
Rapid metabolizer LA25390-8
Normal metabolizer LA25391-6
Intermediate metabolizer LA10317-8
Poor metabolizer LA9657-3

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.73
Order vs. Observation
Observation
Common Test Rank Get Info
14689

Member of these Panels

LOINC Long Common Name
81642-1 CYP3A4 and CYP3A5 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen CYP3A5 interpretation de la actividad en el metabolismo de fármacos:Impresión/interpretación del estudio:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MX Spanish (Mexico) Interpretación de la actividad metabólica del producto del gen CYP3A5:Impresión / interpretación del estudio:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-FR French (France) CYP3A5 gène activité métabolique interprétation:Interprétation:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Interpretazione dell'attività metabolica del gene CYP3A5:Imp:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Farmacogenomica Gene CYP3A5 Genetica molecolare Impressione/interpretazione di studio Interpretazione dell''attività metabolica del gene Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) CYP3A5-gen product metabole activiteit interpretatie:interpretatie:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: CYP3A5 gen product metabole activiteit interpretatie molgen
tr-TR Turkish (Turkey) CYP3A5 geni ürünü metabolik aktivite yorumu:İzlnm:Zmlı:Kan/Dk:Srl:Molgen
zh-CN Chinese (China) CYP3A5 基因产物新陈代谢活性解释:印象:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: CYP3A5 基因产物新陈代谢（代谢）活性解释（说明、阐释、诠释、解释说明）;细胞色素 P450, 家族 3, 亚家族 A, 多肽 5;cytochrome P450, family 3, subfamily A, polypeptide 5 EC 1.14.14.1;细胞色素 P450 家族 3 亚家族 A 成员 5;细胞色素 P450, 亚家族 IIIA (硝苯吡啶氧化酶), 多肽 5;细胞色素 P450, 家族 3, 亚家族 A, 多肽 5;细胞色素 P450 HLp2;细胞色素 P450-PCN3;Cytochrome P450 Family 3 Subfamily A Member 5;Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 代谢作用;新陈代谢 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 判读;解释说明;说明;释义;阐明 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 基因产物新陈代谢（代谢）活性解释（说明、阐释、诠释、解释说明） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 活动 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79717-5