Version 2.77

Term Description

Aluminum CSF levels are measured in studies of the affects of aluminum neuotoxicity in the central nervous system and brain. PMID: 23609067
Source: Regenstrief LOINC

Part Description

LP16800-2   Aluminum
Aluminium (Al) is a metal which is distributed throughout our environment. It has been used since approximately 1887. Al is widely used in multiple industries and consumer products. It has no known function in biology. Al usually enters the human body via cooking utensils or pharmicological agents such as antacids (Al (OH)3 )and antiperspirants. Aluminum salts are remarkably nontoxic, aluminum sulfate having an LD50 of 6207 mg/kg (oral, mouse), which corresponds to 500 grams for an 80 kg (180 lb) person. Aluminum is excreted by filtration by the glomeruli of the kidney. Patients in renal failure lose the ability to clear aluminum, and aluminum toxicity may be a concern. Aluminum accumulates in the blood and binds to proteins such as albumin, and then distributed throughout the body.Because aluminum competes with calcium for absorption, increased amounts of dietary aluminum may contribute to the reduced skeletal mineralization (osteopenia) observed in preterm infants and infants with growth retardation. In very high doses, aluminum is associated with altered function of the blood-brain barrier. A small percentage of people are allergic to aluminum and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminum. In those without allergies, aluminum is not as toxic as heavy metals, but there is evidence of some toxicity if consumed in amounts greater than 40 mg/day per kg of body mass. Aluminum is classified as a non-carcinogen by the US Department of Health and Human Services. In case of suspected sudden intake of a large amount of aluminum, deferoxamine mesylate may be given to help eliminate it from the body by chelation. (Tietz: Clinical Guide to Laboratory Tests, Fourth Edition)
The mechanism of how the neurotoxicity of AI occurs is still unclear. Evidence suggests that oxidative stress and inflammatory processes lead to cell death. As a neurotoxin, Al is considered has been linked to the development of neurodegenerative diseases, including Alzheimer's disease (AD), dementia, Amyotrophic Lateral Sclerosis (ALS) Parkinsonism and even Gulf war syndrome. PMID: 27479193 (for human medicine)

Veterinary Medicine:
In veterinary medicine, the impact of aluminum toxicity is similar. An animal proven to have aluminum toxicity from an ingested foreign body had symptoms of muscle twitching and convulsions during exercise, which worsened to weakened limbs and coma until the source of the toxicity was removed. PMID: 23609067 Source: Regenstrief LOINC

Fully-Specified Name

Component
Aluminum
Property
SCnc
Time
Pt
System
CSF
Scale
Qn
Method

Additional Names

Short Name
Aluminum CSF-sCnc
Display Name
Aluminum (CSF) [Moles/Vol]
Consumer Name Alpha Get Info
Aluminum, Spinal fluid

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.54
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG42676-3 Aluminum|Pt|CSF

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Aluminium:Stoffmengenkonzentration:Zeitpunkt:Liquor:Quantitativ:
Synonyms: Zerebrospinalflüssigkeit
es-ES Spanish (Spain) Aluminio:Concentración de sustancia:Punto temporal:Líquido Cefalorraquideo:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Aluminio:Concentración de sustancias:Punto temporal:Fluído espinal cerebral:Cuantitativo:
et-EE Estonian (Estonia) Alumiinium:SCnc:Pt:CSF:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Liikvor
fr-CA French (Canada) Aluminium:Concentration de substance:Temps ponctuel:LCR:Quantitatif:
fr-FR French (France) Aluminium:Moles/Volume:Ponctuel:Liquide céphalorachidien:Numérique:
fr-BE French (Belgium) Aluminium:Concentration de substance:Temps ponctuel:LCR:Quantitatif:
Synonyms: Al
it-IT Italian (Italy) Alluminio:SCnc:Pt:LCS:Qn:
Synonyms: Concentrazione di Sostanza Liquido cerebrospinale Livelli farmacologici e tossicologia Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) aluminium:mol/volume:moment:liquor cerebrospinalis:kwantitatief:
ru-RU Russian (Russian Federation) Алюминий:МолКонц:ТчкВрм:ЦСЖ:Колич:
Synonyms: Количественный Молярность;Молярная объёмная концентрация Точка во времени;Момент Цереброспинальная жидкость
tr-TR Turkish (Turkey) Aluminyum:SubKons:Zmlı:BOS:Kant:
zh-CN Chinese (China) 铝:物质的量浓度:时间点:脑脊液:定量型:
Synonyms: AL CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类

Example Units

Unit Source
umol/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=80127-4