80176-1
S-adenosylhomocysteine/Creatinine [Molar ratio] in Urine
Active
Part Descriptions
LP200579-3 S-adenosylhomocysteine
S-Adenosylhomocysteine (SAH) is formed by the demethylation of S-adenosylmethionine (SAMe) and is rapidly metabolized to homocysteine. The reaction of SAH to homocysteine is catalyzed by S-adenosylhomocysteine hydrolase and is reversible with the equilibrium favoring formation of SAH. Therefore, increased levels of SAH may occur when the intracellular concentration of homocysteine increases. Since SAH is known to inhibit methylation dependent reactions, the ratio of SAMe to SAH is often used as an index of methylation status. Disturbances in the transmethylation pathway indicated by abnormal SAMe, SAH or their ratio have been reported in many neurodegenerative diseases, such as dementia, depression or Parkinson's disease. PMID: 17892439
Source: Regenstrief LOINC
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Creatinine
Fully-Specified Name
- Component
- S-adenosylhomocysteine/Creatinine
- Property
- SRto
- Time
- Pt
- System
- Urine
- Scale
- Qn
- Method
Additional Names
- Short Name
- SAH/Creat Ur-sRto
- Display Name
- S-adenosylhomocysteine/Creatinine (U) [Molar ratio]
- Consumer Name Alpha Get Info
- S-adenosylhomocysteine/Creatinine, Urine
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.54
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | S-adenosilhomocistina/Creatinina: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | S-adenosilhomocisteína / creatinina: |
fr-FR | French (France) | S-Adénosylhomocystéine/créatinine: |
it-IT | Italian (Italy) | S-adenosilomocisteina/Creatinina: Synonyms: Chimica Punto nel tempo (episodio) Rapporto di sostanza |
nl-NL | Dutch (Netherlands) | S-adenosylhomocysteïne/creatinine: Synonyms: kreatinine |
tr-TR | Turkish (Turkey) | S-adenozilhomosistein/Kreatinin: Synonyms: SubsOranı |
zh-CN | Chinese (China) | S-腺苷同型半胱氨酸/肌酐: Synonyms: CR; |
Example Units
Unit | Source |
---|---|
nmol/mmol{creat} | Example UCUM Units |
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- https:
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