80550-7

Tacrolimus [Mass/volume] in DBS

Active

Term Description

Dried blood spot (DBS) specimens have been used for therapeutic drug monitoring (TDM) across several classes of drugs including antimicrobials, anticonvulsants and immunosuppressants. DBS specimens are useful for TDM in infants and children due to the small sample volume required. DBS specimens are also useful for outpatient TDM in adults who have been trained to collect their own DBS because most analytes are relatively stable in DBS and the DBS card does not require specialized transportation. PMID: 25204403

Part Descriptions

LP15182-6 Tacrolimus
Tacrolimus (also known as FK-506 or Prograf) is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis. It has strong immunosuppressive properties and is commonly used to prevent allograft rejection in transplant recipients. One of its modes of action is to prevent T-lymphocyte activation. Source: National Library of Medicine, MeSH 2006

LP15182-6 Tacrolimus
Tacrolimus (also called FK-506 or fujimycin, Prograf, Advagraf, or Protopic) is amacrolide lactone, calcineurin inhibitor immunosuppresent used mainly after allogeneic organ transplant to lower the risk of organ rejection. It possesses strong immunosuppressive activity by preventing the activation by of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus is also used in a topical preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, TH2-mediated diseases such as Kimura's disease, and the skin condition vitiligo. There are potentially severe side effects from doses that are either too low or too high; inadequate tacrolimus concentrations may result in rejection of the transplanted organ, while high levels may lead to severe adverse effects includin nephrotoxicity, neurotoxicity, gastrointestinal disturbances, diabetogenesis, hypertension and malignant complications. [Wikipedia: Tacrolimus] Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Tacrolimus

LOINC Names Get Info

Fully-Specified Name: Tacrolimus:MCnc:Pt:Bld.dot:Qn:
Long Common Name: Tacrolimus [Mass/volume] in DBS
Short Name: Tacrolimus DBS-mCnc
Display Name: Tacrolimus (DBS) [Mass/Vol]
Consumer Name Alpha Get Info: Tacrolimus, Dried blood spot

Part Model Get Info

Component
Tacrolimus
LP15182-6
- Analyte
  Tacrolimus
  LP15182-6
  - Component Numerator
    Tacrolimus
    LP15182-6
    - Component Numerator Core
      Tacrolimus
      LP15182-6
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld.dot
LP21304-8
- System Core
  Bld.dot
  LP21304-8
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.61 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Takrolimus:Hmotnostní koncentrace:Časový bod:Suchá krevní kapka (DBS):Kvantitativní:
el-GR	Greek (Greece)	Τακρόλιμους:MCnc:Pt:Bld.dot:Qn: Synonyms: Bld.dot DRUG/TOX MCnc Pt Qn Αίμα Τακρόλιμους
es-ES	Spanish (Spain)	Tacrolimus:Concentración de masa:Punto temporal:gota de sangre (papel de filtro):Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Tacrolimus:Concentración de masa:Punto temporal:DBS:Cuantitativo:
et-EE	Estonian (Estonia)	Takroliimus:MCnc:Pt:Vereplekk:Qn: Synonyms: Juhuslik Kvantitatiivne Veri
fr-CA	French (Canada)	Tacrolimus:Concentration de masse:Temps ponctuel:Sang sur papier filtre:Quantitatif:
fr-FR	French (France)	Tacrolimus:Masse/Volume:Ponctuel:Sang buvard:Numérique:
fr-BE	French (Belgium)	Tacrolimus:Concentration de masse:Temps ponctuel:Sang sur papier filtre:Quantitatif:
it-IT	Italian (Italy)	Tacrolimus:MCnc:Pt:Sangue.su carta da filtro:Qn: Synonyms: Concentrazione di Massa FK-506 Livelli farmacologici e tossicologia Punto nel tempo (episodio) Sangue Spot sangue secco
nl-NL	Dutch (Netherlands)	tacrolimus:massa/volume:moment:gedroogde bloedspot:kwantitatief:
ru-RU	Russian (Russian Federation)	Такролимус:МассКонц:ТчкВрм:Кр.Сух.капл:Колич: Synonyms: Количественный Кровь Кровь сухая капля Массовая концентрация Точка во времени;Момент
tr-TR	Turkish (Turkey)	Takrolimus:KütlKons:Zmlı:Kan.nokta:Kant:
zh-CN	Chinese (China)	他克莫司:质量浓度:时间点:全血.斑点:定量型: Synonyms: 全血斑点(滤纸);滤纸;血液.斑点;血液斑点(滤纸) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间普乐可复毒品毒品类水平;浓度;质量浓度(单位体积) 药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血;血液

Example Units

Unit	Source
ug/L	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.