Version 2.80

Part Descriptions

LP206568-0   Floxacillin.free
Floxacillin or flucloxacillin (tradename Flopen or Floxapen) is an isoxazolyl penicillin often used to treat many infections caused by Gram-positive species, such as streptococci and penicillinase-producing staphylococci, including methicillin-susceptible Staphylococcus aureus (MSSA). Studies have shown that flucloxacillin is 95%-97% bound to plasma albumin. The extent of binding to plasma proteins is important, as it is the unbound (free) fraction of drug that produces the pharmacological effect. For critically ill patients, hypoalbuminaemia may be observed, and the effects of hypoalbuminaemia on the pharmacokinetics of highly bound antiboitics may pose a potential risk for inappropriate antibiotic therapy in these patients. PMID: 20530507 Source: Regenstrief LOINC , PMID: 20530507

LP207910-3   free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity. Source: Regenstrief LOINC

Fully-Specified Name

Component
Floxacillin.free
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Long Common Name
Floxacillin Free [Mass/volume] in Serum or Plasma
Short Name
Floxacillin free SerPl-mCnc
Display Name
Floxacillin Free [Mass/Vol]
Consumer Name Alpha Get Info
Free floxacillin, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.56 (ADD)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Φλοξακιλλίνη.ελεύθερη:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc Φλοξακιλλίνη Φλοξακιλλίνη.ελεύθερη
es-MX Spanish (Mexico) Floxacilina libre:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Floxacilina libre:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Floxacilline libre:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-IT Italian (Italy) Floxacillina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NL Dutch (Netherlands) flucloxacilline.vrij:massa/volume:moment:serum of plasma:kwantitatief:
zh-CN Chinese (China) 氟氯西林.游离型:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 氟氯唑青霉素;氟氯苯唑青霉素;氟氯苯甲异恶唑青霉素;氟氯青霉素;氟沙星 氟氯西林（氟氯唑青霉素、氟氯苯唑青霉素、氟氯苯甲异恶唑青霉素、氟氯青霉素、氟沙星）.游离型;游离型（游离）氟氯西林（氟氯唑青霉素、氟氯苯唑青霉素、氟氯苯甲异恶唑青霉素、氟氯青霉素、氟沙星） 水平;浓度;质量浓度(单位体积) 游离 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆 非蛋白结合型 非蛋白质结合型

Example Units

Unit Source
mg/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=80642-2