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Term Description

Qualitative detection of nucleic acid sequences in the Clostridium difficile toxin A (tcdA) and B (tcdB) genes in stool specimens by real-time PCR methods. This assay does not differentiate between C. difficile toxin A and B genes. This term was created for, but not limited in use to, the submitter's test kit, xTAG® Gastrointestinal Pathogen Panel (GPP).

Part Description

LP204848-8   Clostridioides difficile toxin A+B tcdA+tcdB genes
Clostridium difficile toxin's A and B are encoded by the tcdA and tcdB genes, respectively. PMID: 20664812 They share similar molecular characteristics with comparable sizes (308 kD for tcdA and 269 for tcdB) and 63% homology in their amino acid sequences. PMID: 9312171 TcdA and tcdB are expressed in response to environmental stresses, such as antibiotics.[ PMID 15831824] Nucleic acid sequences within these genes are targeted to confirm the presence of C. difficile toxins and diagnose the cause of diarrhea, abdominal pain, fever, nausea and other toxin-producing symptoms. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Clostridioides difficile toxin A+B tcdA+tcdB genes:PrThr:Pt:Stool:Ord:Probe.amp.tar
Long Common Name
Clostridioides difficile toxin A+B tcdA+tcdB genes [Presence] in Stool by NAA with probe detection
Short Name
C dif tox tcdA+tcdB Stl Ql NAA+probe
Display Name
C. difficile toxin A+B tcdA+tcdB genes NAA+probe Ql (Stl)
Consumer Name Alpha Get Info
Clostridioides difficile toxin A+B tcdA+tcdB genes, Stool

Part Model Get Info

  • Component
    Clostridioides difficile toxin A+B tcdA+tcdB genes
    LP204848-8
    • Analyte
      Clostridioides difficile toxin A+B tcdA+tcdB genes
      LP204848-8
      • Component Numerator
        Clostridioides difficile toxin A+B tcdA+tcdB genes
        LP204848-8
        • Component Numerator Core
          Clostridioides difficile toxin A+B tcdA+tcdB genes
          LP204848-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Stool
    LP7604-4
    • System Core
      Stool
      LP7604-4
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Probe.amp.tar
    LP6464-4

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.73 (MIN)
Change Reason
Removed parentheses around the gene names in the Component based on the current LOINC model; Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation
Both
Common Test Rank Get Info
10075

Member of these Panels

LOINCLong Common Name
95183-0Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection
79381-0Gastrointestinal pathogens panel - Stool by NAA with probe detection

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Clostridioides difficile toxin A+B geny tcdA+tcdB:Přítomnost nebo práh:Časový bod:Stolice:Ordinální:Amplifikace nukleových kyselin s detekcí sondou
de-DEGerman (Germany)Clostridioides difficile Toxine A+B tcdA+tcdB-Gene:Nachweis oder Schwellenwert:Zeitpunkt:Stuhl:Ordinal:Zielfragmentamplifikation mit Sondendetektion
de-ATGerman (Austria)Synonyms: Clostridium difficile bin. Toxin-Gene /ST ql. PCR
el-GRGreek (Greece)Γονίδια tcdA+tcdB τοξίνης Α+Β του Clostridioides difficile:PrThr:Pt:Κόπρανα:Ord:Ανιχνευτής.ενίσχυση.στόχου
Synonyms: A A,B B Clostridioides difficile MICRO Ord PrThr Pt Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Γονίδια tcdA+tcdB τοξίνης Α+Β του Clostridioides difficile Κόπρανα Τοξίνη Α του Clostridioides difficile Τοξίνη Α+Β του Clostridioides difficile Τοξίνη του Clostridioides difficile
es-ESSpanish (Spain)Gen de la toxina del Clostridium difficile A+B (tcdA+tcdB):PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida
es-MXSpanish (Mexico)Toxina de Clostridioides difficile A + B genes tcdA + tcdB:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FRFrench (France)Clostridioides difficile toxines A+B gènes tcdA+tcdB:Présence/Seuil:Ponctuel:Selle:Qualitatif:PCR amplification de cible
it-ITItalian (Italy)Clostridium Difficile (tcdA+tcdB), geni tossine A+B:PrThr:Pt:Feci:Ord:Sonda.amp.tar
Synonyms: Geni delle tossine A+B del Clostridium Difficile ( Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Tossina A di Clostridium difficile Tossina A+B di Clostridium difficile Tossina di Clostridium difficile
nl-NLDutch (Netherlands)Clostridioides difficile toxine A+B (tcdA+tcdB) genen:aanwezigheid:moment:feces:ordinaal:probe-detectie
Synonyms: Clostridium difficile Clostridium difficile toxine Clostridium difficile toxine A Clostridium difficile toxine A+B Clostridium difficile toxine A+B (tcdA+tcdB) genen ontlasting; feces probe.amp.tar
pl-PLPolish (Poland)Clostridioides difficile toksyny A+B tcdA+tcdB geny:granica wykrywalności:punkt w czasie:kał:uporządkowany:sonda.amplifikacja.cel
Synonyms: amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy Geny tcdA i tcdB kodujące toksyny A i B Clostridioides difficile
zh-CNChinese (China)艰难梭菌毒素 A+B tcdA+tcdB 基因:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
Synonyms: A 型 A,B 型;AB 型 B 型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 分子病理学 - 基因类 基因 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 艰难梭状芽胞杆菌;艰难芽孢梭菌 艰难梭状芽胞杆菌毒素 A;艰难梭状芽胞杆菌毒素 A 型;艰难梭菌毒素 A 型;艰难芽孢梭菌毒素 A;艰难芽孢梭菌毒素 A 型 艰难梭状芽胞杆菌毒素 A+B;艰难梭状芽胞杆菌毒素 A+B 型;艰难梭菌毒素 A+B 型;艰难芽孢梭菌毒素 A+B;艰难芽孢梭菌毒素 A+B 型 艰难梭状芽胞杆菌毒素;艰难芽孢梭菌毒素 艰难梭菌毒素（艰难梭状芽胞杆菌、艰难芽孢梭菌） A+B tcdA+tcdB 基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=80685-1