Version 2.80

Part Descriptions

LP200620-5   Cells.CD27-CD45RA+
CD27 and CD45RA are both lymphocyte cell surface markers that can be used to classify T-cells into various subsets. Expression of CD27 is characteristic of naive T-cells and some subsets of memory T-cells, while lack of CD27 is characteristic of effector T-cells. PMID: 19454729. CD45RA is characteristic of resting or naive T-cells. Cells expressing both CD27+CD45RA+ are undifferentiated (naive), CD27+CD45RA- T-cells are at an early stage of differentiation and exhibit characteristics of memory T cells, whereas CD27-CD45RA- T-cells are highly differentiated and have characteristics of both memory and effector T-cells. PMID: 12023349 PMID: 21788446 Source: Regenstrief LOINC

LP99724-4   Cells.CD3+CD4+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP20086-2   CD45RA
Found on Naive helper T-cells, B-cells and Granulocytes
Associated with some T-cell lymphomas and some mature B-cell lymphomas Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD27-CD45RA+/Cells.CD3+CD4+
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Long Common Name
CD27-CD45RA+ cells/CD3+CD4+ (T4 helper) cells in Blood
Short Name
CD27-CD45RA+ cells/CD3+CD4+ NFr Bld
Display Name
CD27-CD45RA+ cells/CD3+CD4+ (T4 helper) cells (Bld)
Consumer Name Alpha Get Info
CD27-CD45RA+ cells/CD3+CD4+ (T4 Helper) Cells, Blood

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
80720-6 T-cell naive and memory and effector (CD27 and CD45RA) subsets panel - Blood

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κύτταρα.CD27-CD45RA+/Κύτταρα.CD3+CD4+:NFr:Pt:Αίμα:Qn:
Synonyms: CD27 CD3 CD4 CD45RA NFr Κύτταρα Κύτταρα.CD27 Κύτταρα.CD27- Κύτταρα.CD27+CD45RA- Κύτταρα.CD27+CD45RA+ Κύτταρα.CD27-CD45RA- Κύτταρα.CD27-CD45RA+ Κύτταρα.CD3 Κύτταρα.CD3+CD4+ Κύτταρα.CD3-CD4+
es-ES Spanish (Spain) Células CD27-CD45RA+/Células CD3+CD4+:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.CD27-CD45RA + / 100 Cells.CD3 + CD4 +:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) CD27-CD45RA+/100 cellules CD3+CD4+:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD27-CD45RA+/Cellule.CD3+CD4+:NFr:Pt:Sangue:Qn:
Synonyms: Cellule CD27 Cellule CD27- Cellule CD27+CD45RA- Cellule CD27+CD45RA+ Cellule CD27-CD45RA- Cellule CD27-CD45RA+ Cellule CD3 Cellule CD3+CD4+ Cellule CD3+CD4+ (T4 aiutanti) Cellule CD3-CD4+ Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) cellen.CD27-CD45RA+/cellen.CD3+CD4+:getalsfractie:moment:bloed:kwantitatief:
zh-CN Chinese (China) 细胞.CD27-CD45RA+/细胞.CD3+CD4+:计数型分数:时间点:全血:定量型:
Synonyms: CD27细胞 CD3+CD4+细胞 CD3-CD4+细胞 CD3细胞 CD45RA L3T4 Leu18 Leu-18 Leu3 Leu-3 Leu4;Leu-4;T3 S152 T14 T4 T-4 W3/25 发现于原态辅助 T-细胞、B-细胞以及粒细胞之上。与一些 T-细胞淋巴瘤和一些成熟 B-细胞淋巴瘤相关。 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=80709-9