80974-9
Sulfamethoxazole free [Mass/volume] in Serum or Plasma
Active
Part Descriptions
LP207773-5 Sulfamethoxazole.free
Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic. It is most often used as part of a synergistic combination with trimethoprim in a 5:1 ratio in co-trimoxazole, which is also known as Bactrim or Septrin. It can be used as an alternative to amoxicillin -based antibiotics to treat sinusitis. Mechanism of action:Sulfonamides are structural anologs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of folic acid, an important metabolite in DNA synthesis. The effects seen are usually bacteriostatic in nature. Folic acid is not synthesized in humans, but is instead a dietary requirement. This allows for the selective toxicity to bacterial cells (or any cell dependent on synthesizing folic acid) over human cells.
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Source: Wikipedia,
Sulfamethoxazole (Wikipedia)
LP207910-3 free DRUG/TOX
The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug PMID: 6636249. For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity.
Source: Regenstrief LOINC
LOINC Names Get Info
- Fully-Specified Name
- Sulfamethoxazole.free:
MCnc: Pt: Ser/Plas: Qn: - Long Common Name
- Sulfamethoxazole free [Mass/volume] in Serum or Plasma
- Short Name
- Sulfamethoxazole free SerPl-mCnc
- Display Name
- Sulfamethoxazole free [Mass/Vol]
- Consumer Name Alpha Get Info
- Free sulfamethoxazole, Blood
Part Model Get Info
- Component
- Sulfamethoxazole.free
LP207773-5
- Analyte
- Sulfamethoxazole.free
LP207773-5
- Component Numerator
- Sulfamethoxazole.free
LP207773-5
- Component Numerator Core
- Sulfamethoxazole.free
LP207773-5
- Component Numerator Core Suffix
- NULL
- Component Denominator
- NULL
- Component Denominator Core
- NULL
- Component Denominator Core Suffix
- NULL
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- MCnc
LP6827-2
- Time
- Pt
LP6960-1
- Time Core
- Pt
LP6960-1
- Time Modifier
- NULL
- System
- Ser/Plas
LP7576-4
- System Core
- Ser/Plas
LP7576-4
- Super System
- NULL
- Scale
- Qn
LP7753-9
- Method
- NULL
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.56
- Last Updated
- Version 2.56 (ADD)
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Sulfamethoxazol volný: |
| el-GR | Greek (Greece) | Σουλφαμεθοξαζόλη.ελεύθερη: Synonyms: DRUG/TOX MCnc Pt Qn Ορός Ορός/Πλάσμα Πλάσμα Σουλφαμεθοξαζόλη Σουλφαμεθοξαζόλη.ελεύθερη |
| es-ES | Spanish (Spain) | Sulfometoxazol libre: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Sulfametoxazol libre: |
| fr-FR | French (France) | Sulfaméthoxazole libre: |
| it-IT | Italian (Italy) | Sulfametossazolo.libero: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sulfametossazolo libero |
| nl-NL | Dutch (Netherlands) | sulfamethoxazol.vrij: |
| zh-CN | Chinese (China) | 磺胺甲噁唑.游离型: Synonyms: SMX; |
Example Units
| Unit | Source |
|---|---|
| mg/L | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://