Version 2.78

Term Description

This assay will detect mutations in exons 2, 3 and 4 of both the KRAS and NRAS genes, allowing the determination of drug response. This term was created for, but not limited in use to, the ABI PRISM SNaPshot Multiplex Kit.
Source: Regenstrief LOINC

Part Descriptions

LP207788-3   KRAS & NRAS gene
The KRAS gene (Kirsten rat sarcoma viral oncogene homolog) [HGNC Gene ID:6407] is located on chromosome 12p12.1. This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008] [NCBI Gene ID:3845] Source: National Center for Biotechnology Information (NCBI) Gene

LP207788-3   KRAS & NRAS gene
The NRAS gene (neuroblastoma RAS viral (v-ras) oncogene homolog) [HGNC Gene ID:7989] is located on chromosome 1p13.2. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] [NCBI Gene ID:4893] Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component
KRAS & NRAS gene targeted mutation analysis
Property
Prid
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Short Name
KRAS + NRAS Mut Anl Bld/T
Display Name
KRAS and NRAS gene targeted mutation analysis Molgen Nom (Bld/Tiss)
Consumer Name Alpha Get Info
KRAS and NRAS gene targeted mutation analysis, Blood or tissue specimen

Example Answer List: LL3941-3

Source: Laboratory Corporation of America
Answer Code Score Answer ID
NEGATIVE - No KRAS or NRAS mutations were detected in exons 2, 3 and 4 LA26004-4
POSITIVE - NRAS mutation was detected in the provided specimen. No KRAS mutations were detected in exons 2, 3 and 4. No KRAS mutations were detected in exons 2, 3 and 4. LA26005-1
POSITIVE - KRAS mutation was detected in the provided specimen. No NRAS mutations were detected in exons 2, 3 and 4. POSITIVE LA26006-9
POSITIVE - KRAS and NRAS mutations were detected in the provided specimen LA26007-7

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
16799

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen KRAS y NRAS Analisis de mutaciones:Presencia o identidad:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Análisis de mutaciones dirigidas al gen KRAS y NRAS:Presencia o identidad:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) KRAS et NRAS gène mutation cible trouvée:Identification:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) KRAS & NRAS, geni analisi di mutazione mirata:Prid:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Gene NRAS Genetica molecolare Geni KRAS & NRAS Mutazione genica Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) KRAS & NRAS-gen doelgerichte mutatie-analyse:identificator:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: KRAS & NRAS gen molgen NRAS gen targeted
zh-CN Chinese (China) KRAS 与 NRAS 基因 突变分析:存在与否或特征标识:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: Kirsten大鼠肉瘤病毒癌基因同源物;神经母细胞瘤 RAS 病毒癌基因同源物;Kirsten Rat Sarcoma Viral Oncogene Homolog;KRAS 基因;Neuroblastoma RAS Viral Oncogene Homolog;NRAS 基因 v-ras 成神经细胞瘤 RAS 病毒癌基因同源基因;v-ras 神经母细胞瘤 RAS 病毒癌基因同源基因;癌基因 NRAS;致癌基因 NRAS 全血或组织;血液/组织;血液或组织 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 基因突变分析 存在;存在与否;特征标识;身份;身份标识 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

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