81420-2

KRAS and NRAS gene mutations found [Identifier] in Blood or Tissue by Targeted gene mutation analysis Nominal

Active

Term Description

This assay will detect mutations in exons 2, 3 and 4 of both the KRAS and NRAS genes, allowing the determination of drug response. This term was created for, but not limited in use to, the ABI PRISM SNaPshot Multiplex Kit.

Part Descriptions

LP207788-3 KRAS & NRAS gene
The KRAS gene (Kirsten rat sarcoma viral oncogene homolog) [HGNC Gene ID:6407] is located on chromosome 12p12.1. This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008] [NCBI Gene ID:3845] Source: National Center for Biotechnology Information (NCBI) Gene

LP207788-3 KRAS & NRAS gene
The NRAS gene (neuroblastoma RAS viral (v-ras) oncogene homolog) [HGNC Gene ID:7989] is located on chromosome 1p13.2. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] [NCBI Gene ID:4893] Source: National Center for Biotechnology Information (NCBI) Gene

LOINC Names Get Info

Fully-Specified Name: KRAS & NRAS gene mutations:Prid:Pt:Bld/Tiss:Nom:Targeted gene mutation analysis
Long Common Name: KRAS and NRAS gene mutations found [Identifier] in Blood or Tissue by Targeted gene mutation analysis Nominal
Short Name: KRAS + NRAS Mut Bld/T Mut Anl
Display Name: KRAS and NRAS gene mutations found Targeted gene mutation analysis Nom (Bld/Tiss)
Consumer Name Alpha Get Info: KRAS and NRAS gene mutations found, Blood or tissue specimen

Part Model Get Info

Component
KRAS & NRAS gene mutations
LP452193-8
- Analyte
  KRAS & NRAS gene mutations
  LP452193-8
  - Component Numerator
    KRAS & NRAS gene mutations
    LP452193-8
    - Component Numerator Core
      KRAS & NRAS gene
      LP207788-3
    - Component Numerator Core Suffix
      mutations
      LP452208-4
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Prid
LP6850-4
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld/Tiss
LP7061-7
- System Core
  Bld/Tiss
  LP7061-7
- Super System
  NULL
Scale
Nom
LP7750-5
Method
Targeted gene mutation analysis
LP95475-7

Example Answer List: LL3941-3

Source: Laboratory Corporation of America

Answer	Code	Score	Answer ID
NEGATIVE - No KRAS or NRAS mutations were detected in exons 2, 3 and 4			LA26004-4
POSITIVE - NRAS mutation was detected in the provided specimen. No KRAS mutations were detected in exons 2, 3 and 4. No KRAS mutations were detected in exons 2, 3 and 4.			LA26005-1
POSITIVE - KRAS mutation was detected in the provided specimen. No NRAS mutations were detected in exons 2, 3 and 4. POSITIVE			LA26006-9
POSITIVE - KRAS and NRAS mutations were detected in the provided specimen			LA26007-7

Basic Attributes

Class: MOLPATH.MUT
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.83 (NAM)
Order vs. Observation: Both
Common Test Rank Get Info: 16799

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Gen KRAS & NRAS cílená mutační analýza:Přítomnost nebo identita:Časový bod:Krev/tkáň:Nominální:Molekulární genetika
el-GR	Greek (Greece)	Γονίδιο KRAS & NRAS στοχευμένη ανάλυση μεταλλάξεων:Prid:Pt:Αίμα/Ιστός:Nom:Μοριακή γενετική Synonyms: MOLPATH MOLPATH.MUT Nom Prid Pt Αίμα Αίμα/Ιστός Γονίδιο Γονίδιο KRAS & NRAS Γονίδιο NRAS Ιστός Μοριακή γενετική στοχευμένη ανάλυση μεταλλάξεων
es-MX	Spanish (Mexico)	Análisis de mutaciones dirigidas al gen KRAS y NRAS:Presencia o identidad:Punto temporal:Sangre o tejido:Nominal:Genética molecular
es-ES	Spanish (Spain)	Gen KRAS y NRAS Analisis de mutaciones:Presencia o identidad:Punto temporal:Sangre o tejido:Nom:Genética molecular
fr-FR	French (France)	KRAS et NRAS gène mutation cible trouvée:Identification:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT	Italian (Italy)	KRAS & NRAS, geni analisi di mutazione mirata:Prid:Pt:Sangue/Tess:Nom:Molgen Synonyms: Gene NRAS Genetica molecolare Geni KRAS & NRAS Mutazione genica Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL	Dutch (Netherlands)	KRAS & NRAS-gen doelgerichte mutatie-analyse:identificator:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek Synonyms: KRAS & NRAS gen molgen NRAS gen targeted
pl-PL	Polish (Poland)	KRAS & NRAS gen ukierunkowana analiza mutacji:obecność lub identyfikacja:punkt w czasie:krew lub tkanka:skala nominalna:genetyka molekularna Synonyms: Analiza mutacji genów KRAS i NRAS Analiza mutacji genu NRAS diagnostyka molekularna Gen KRAS i NRAS Gen NRAS wynik kategorialny
zh-CN	Chinese (China)	KRAS 与 NRAS 基因突变分析:存在与否或特征标识:时间点:全血/组织:名义型:分子遗传学类实验室方法 Synonyms: Kirsten大鼠肉瘤病毒癌基因同源物;神经母细胞瘤 RAS 病毒癌基因同源物;Kirsten Rat Sarcoma Viral Oncogene Homolog;KRAS 基因;Neuroblastoma RAS Viral Oncogene Homolog;NRAS 基因 v-ras 成神经细胞瘤 RAS 病毒癌基因同源基因;v-ras 神经母细胞瘤 RAS 病毒癌基因同源基因;癌基因 NRAS;致癌基因 NRAS 全血或组织;血液/组织;血液或组织分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答基因突变分析存在;存在与否;特征标识;身份;身份标识时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片血;血液遗传基因;遗传因子;吉恩;生物基因

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