Version 2.80

Term Description

Elevated lactate dehydrogenase is a marker for various types of tissue injury. In patients undergoing peritoneal dialysis, elevated LDH in the dialysate may be a sign of peritonitis, and failure of dialysate LDH levels to normalize during treatment of peritonitis may be associated with incomplete recovery and a higher rate of complications compared to patients whose LDH levels decrease back to normal levels. PMID: 7948233

Part Descriptions

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , D-lactate (Wikipedia)

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. PMID: 3882046. Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition] Source: Regenstrief LOINC

Fully-Specified Name

Component
Lactate dehydrogenase
Property
CCnc
Time
Pt
System
Dial fld prt
Scale
Qn
Method
Reaction: lactate to pyruvate

Additional Names

Long Common Name
Lactate dehydrogenase [Enzymatic activity/volume] in Peritoneal dialysis fluid by Lactate to pyruvate reaction
Short Name
LDH DiafP L to P-cCnc
Display Name
LDH Lactate to pyruvate reaction (Perit dial fld) [Catalytic activity/Vol]
Consumer Name Alpha Get Info
Lactate Dehydrogenase (LDH), Peritoneal dialysis fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.68 (MIN)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Lactatdehydrogenase:Katalytische Konzentration:Zeitpunkt:Peritonealdialysat:Quantitativ:Reaktion: Lactat zu Pyruvat
Synonyms: LDH
el-GR Greek (Greece) Γαλακτική αφυδρογονάση:CCnc:Pt:Περιτοναϊκό υγρό prt:Qn:Αντίδραση: γαλακτικό προς πυροσταφυλικό
Synonyms: CCnc Γαλακτική αφυδρογονάση Γαλακτικό οξύ
es-ES Spanish (Spain) Lactato deshidrogenasa:Concentración Catalítica:Punto temporal:Dialisis líquido peritoneal:Qn:Reacción - lactato piruvato
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Lactato deshidrogenasa:Concentración catalítica:Punto temporal:Líquido de diálisis peritoneal:Cuantitativo:Reacción - lactato a piruvato
fr-CA French (Canada) Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Solution de dialyse péritonéale:Quantitatif:Réaction: lactate en pyruvate
fr-FR French (France) Lactate déhydrogénase:Catalytique/Volume:Ponctuel:Liquide de dialyse péritonéale:Numérique:Réaction : Lactate vers Pyruvate
fr-BE French (Belgium) Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Solution de dialyse péritonéale:Quantitatif:Réaction: lactate en pyruvate
Synonyms: LDH
it-IT Italian (Italy) Lattato deidrogenasi:CCnC:Pt:Liquido di dialisi peritoneale:Qn:Reazione: lattato in piruvato
Synonyms: Chimica Concentrazione Catalitica Dialisato Liquido di dialisi peritoneale Punto nel tempo (episodio) Reazione- lattato in piruvato
nl-NL Dutch (Netherlands) lactaatdehydrogenase:enzymatische activiteit/volume:moment:periteonale dialysevloeistof:kwantitatief:reactie: lactaat naar pyruvaat
pl-PL Polish (Poland) Dehydrogenaza mleczanowa:stężenie katalityczne:punkt w czasie:płyn dializacyjny otrzewnowy:ilościowy:reakcja L-P, mleczan-pirogronian
tr-TR Turkish (Turkey) Laktat dehidrojenaz:KtlKons:Zmlı:Diyal sv prt:Kant:Reaksiyon: laktat tan piruvat a
zh-CN Chinese (China) 乳酸脱氢酶:催化浓度:时间点:腹膜透析液:定量型:反应: 乳酸至丙酮酸
Synonyms: 2-羟基-丙酸;Lact;L-乳酸 L.D.H;LD;LDH;L-乳酸脱氢酶 React Rxn 乳酸 - 丙酮酸转化法;乳酸 -> 丙酮酸转化法;乳酸转化为丙酮酸的反应;反应: 乳酸 - 丙酮酸;反应: 乳酸 -> 丙酮酸 催化浓度(单位体积);单位体积内酶的单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 去氢酶 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 渗析液;透析物

Example Units

Unit Source
U/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81430-1