Version 2.80

Term Description

The overall interpretation of methotrexate polyglutamates (MTX-PGs) measurement results in red blood cells. Results are used to guide treatment planning and evaluation for various diseases, including rheumatoid arthritis.

Part Description

LP188434-7   Methotrexate polyglutamates
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700 Source: Regenstrief LOINC , PMID: 15677700

Fully-Specified Name

Component
Methotrexate polyglutamates
Property
Imp
Time
Pt
System
RBC
Scale
Nar
Method

Additional Names

Long Common Name
Methotrexate polyglutamates [Interpretation] in Red Blood Cells Narrative
Short Name
MTX-PGs RBC-Imp
Display Name
Methotrexate polyglutamates Nar (RBC) [Interp]
Consumer Name Alpha Get Info
Interpretation of Methotrexate polyglutamates test result, Red blood cells

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.56 (ADD)
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
81630-6 Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Πολυγλουταμινική μεθοτρεξάτη:Imp:Pt:Ερυθρά αιμοσφαίρια:Nar:
Synonyms: Imp Μεθοτρεξάτη Πολυγλουταμινική μεθοτρεξάτη
es-ES Spanish (Spain) Metotrexato poliglutamato:Impresión/interpretación del estudio:Punto temporal:Glóbulos rojos:Narrativo:
es-MX Spanish (Mexico) Poliglutamatos de metotrexato:Impresión / interpretación del estudio:Punto temporal:Eritrocitos:Narrativo:
fr-FR French (France) Méthotrexate polyglutamates:Interprétation:Ponctuel:Érythrocytes:Résultat textuel:
it-IT Italian (Italy) Metotrexato poliglutammati:Imp:Pt:RBC:Nar:
Synonyms: Globuli rossi Impressione/interpretazione di studio Livelli farmacologici e tossicologia Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) methotrexaat-polyglutamaat:interpretatie:moment:erytrocyten:tekstueel:
Synonyms: rode bloedcellen
tr-TR Turkish (Turkey) Metotreksat poliglutamat:İzlnm:Zmlı:Eritrosit:Öykü:
Synonyms: RBC
zh-CN Chinese (China) 氨甲蝶呤多聚谷氨酸:印象:时间点:红细胞:叙述型:
Synonyms: C20H22N8O5;甲氨喋呤;氨甲基叶酸;氨甲蝶呤;甲基蝶啶胺;甲基蝶啶胺(化学不孕剂) RBC;RBCS;红血球;红血细胞;赤血球 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 毒品 毒品类 氨甲蝶呤（甲氨喋呤、氨甲基叶酸、氨甲蝶呤、甲基蝶啶胺）多聚谷氨酸;聚谷氨酸化甲氨蝶呤;多聚谷氨酸化甲氨蝶呤;MTX-PG;MTXPG;MTX-PGs;MTXPGs 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81631-4