Version 2.80

Description

Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700 Source: Regenstrief LOINC , PMID: 15677700

Basic Part Properties

Part Name
Methotrexate polyglutamates
Part Display Name
Methotrexate polyglutamates
Part Type
Component (Describes the core component or analyte measured)
Created On
2014-12-29
Construct for LOINC Short Name
MTX-PGs

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP188434-7

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 氨甲蝶呤多聚谷氨酸
Synonyms: 氨甲蝶呤（甲氨喋呤、氨甲基叶酸、氨甲蝶呤、甲基蝶啶胺）多聚谷氨酸;聚谷氨酸化甲氨蝶呤;多聚谷氨酸化甲氨蝶呤;MTX-PG;MTXPG;MTX-PGs;MTXPGs
it-IT Italian (Italy) Metotrexato poliglutammati
tr-TR Turkish (Turkey) Metotreksat poliglutamat
es-ES Spanish (Spain) Metotrexato poliglutamato
nl-NL Dutch (Netherlands) methotrexaat-polyglutamaat
el-GR Greek (Greece) Πολυγλουταμινική μεθοτρεξάτη
Synonyms: Πολυγλουταμινική μεθοτρεξάτη