BRAF protein [Presence] in Cancer specimen by Immune stain
LP212224-2 Serine-threonine protein kinase B-raf
The BRAF gene (B-Raf proto-oncogene, serine/threonine kinase) [HGNC Gene ID:1097] is located on chromosome 7q34. This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:673] Loss of the BRAF gene can be determined by various techniques, and loss of the protein, which is an indicator of gene mutation or deletion, can be detected by immunohistochemistry techniques. Source: National Center for Biotechnology Information (NCBI) Gene
- Serine-threonine protein kinase B-raf
- Cancer specimen
- Immune stain
- Short Name
- BRAF protein Ca spec Ql ImStn
- Display Name
- BRAF protein Immune stain Ql (Cancer specimen)
- Consumer Name Alpha
- BRAF protein, Cancer specimen
Example Answer List: LL2038-9Source: Quest Diagnostics Inc.
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
|IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)||LA11884-6|
- First Released
- Version 2.56
- Last Updated
- Version 2.61
- Change Reason
- Updated System from "Tiss" to "Cancer.XXX" because BRAF protein immune staining is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
- Order vs. Observation
Member of these Panels
|LOINC||Long Common Name|
|85905-8||Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols|
|zh-CN||Chinese (China)||丝氨酸-苏氨酸蛋白激酶 B-raf:
|es-ES||Spanish (Spain)||B-raf serina-treonina protein quinasa:
|it-IT||Italian (Italy)||Serina-treonina proteina chinasi B-raf:
|es-MX||Spanish (Mexico)||Serina-treonina proteína quinasa B-raf:
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