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Part Description

LP212224-2   Serine-threonine protein kinase B-raf
The BRAF gene (B-Raf proto-oncogene, serine/threonine kinase) [HGNC Gene ID:1097] is located on chromosome 7q34. This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:673] Loss of the BRAF gene can be determined by various techniques, and loss of the protein, which is an indicator of gene mutation or deletion, can be detected by immunohistochemistry techniques. Source: National Center for Biotechnology Information (NCBI) Gene

LOINC Names Get Info

Fully-Specified Name
Serine-threonine protein kinase B-raf Ag:PrThr:Pt:Cancer specimen:Ord:Immune stain
Long Common Name
BRAF protein Ag [Presence] in Cancer specimen by Immune stain
Short Name
BRAF protein Ag Ca spec Ql ImStn
Display Name
BRAF protein Ag Immune stain Ql (Cancer specimen)
Consumer Name Alpha Get Info
BRAF protein antigen, Cancer specimen

Part Model Get Info

  • Component
    Serine-threonine protein kinase B-raf Ag
    LP450032-0
    • Analyte
      Serine-threonine protein kinase B-raf Ag
      LP450032-0
      • Component Numerator
        Serine-threonine protein kinase B-raf Ag
        LP450032-0
        • Component Numerator Core
          Serine-threonine protein kinase B-raf
          LP212224-2
        • Component Numerator Core Suffix
          Ag
          LP20666-1
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Cancer specimen
    LP247830-5
    • System Core
      Cancer specimen
      LP247830-5
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Immune stain
    LP6333-1

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)LA11884-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.82 (NAM)
Change Reason
Updated System from "Tiss" to "Cancer.XXX" because BRAF protein immune staining is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
85905-8Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)BRAF protein:Přítomnost nebo práh:Časový bod:Vzorek karcinomu:Ordinální:Imunobarvení
el-GRGreek (Greece)Πρωτεϊνική κινάση σερίνης-θρεονίνης B-raf Αντιγόνο:PrThr:Pt:Δείγμα καρκίνου:Ord:Ανοσολογική χρώση
Synonyms: B Ord PATH PrThr Pt Ανοσολογική χρώση Αντιγόνο Δείγμα Δείγμα καρκίνου Θρεονίνη Καρκίνος Πρωτεΐνη Πρωτεϊνική κινάση Πρωτεϊνική κινάση σερίνης-θρεονίνης B-raf Σερίνη
es-ESSpanish (Spain)B-raf serina-treonina protein quinasa Antígeno:PrThr:Punto temporal:Muestra de cancer:Ord:Tinción de inmunohistoquímica
es-MXSpanish (Mexico)Serina-treonina proteína quinasa B-raf:Presencia o umbral:Punto temporal:Espécimen de cáncer:Ordinal:Mancha inmune
it-ITItalian (Italy)Serina-treonina proteina chinasi B-raf, Ag:PrThr:Pt:Campione tumore:Ord:Colorazione immunologica
Synonyms: Campione di tumore Neoplasia maligna Patologia PKA Presenza o Soglia Proteina BRAF Punto nel tempo (episodio)
pl-PLPolish (Poland)Kinaza białkowa serynowo-treoninowa B-raf Ag:granica wykrywalności:punkt w czasie:próbka nowotworu:uporządkowany:barwienie immunohistochemiczne
Synonyms: nowotwór
zh-CNChinese (China)丝氨酸-苏氨酸蛋白激酶 B-raf 抗原:存在情况或阈值:时间点:癌标本:序数型:免疫染色法
Synonyms: Ag B 型 Beta-羟丁氨酸;Thr;β-羟丁氨酸;羟基丁氨酸 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 Ser STK B-raf 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 染法 染色方法 染色法 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 着色 着色方法 着色法 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81705-6