Version 2.78

Part Description

LP212224-2   Serine-threonine protein kinase B-raf
The BRAF gene (B-Raf proto-oncogene, serine/threonine kinase) [HGNC Gene ID:1097] is located on chromosome 7q34. This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:673] Loss of the BRAF gene can be determined by various techniques, and loss of the protein, which is an indicator of gene mutation or deletion, can be detected by immunohistochemistry techniques. Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component
Serine-threonine protein kinase B-raf
Property
PrThr
Time
Pt
System
Cancer specimen
Scale
Ord
Method
Immune stain

Additional Names

Short Name
BRAF protein Ca spec Ql ImStn
Display Name
BRAF protein Immune stain Ql (Cancer specimen)
Consumer Name Alpha Get Info
BRAF protein, Cancer specimen

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.61
Change Reason
Updated System from "Tiss" to "Cancer.XXX" because BRAF protein immune staining is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85905-8 Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) B-raf serina-treonina protein quinasa:PrThr:Punto temporal:Muestra de cancer:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Serina-treonina proteína quinasa B-raf:Presencia o umbral:Punto temporal:Espécimen de cáncer:Ordinal:Mancha inmune
it-IT Italian (Italy) Serina-treonina proteina chinasi B-raf:PrThr:Pt:Campione tumore:Ord:Colorazione immunologica
Synonyms: Campione di tumore Neoplasia maligna Patologia PKA Presenza o Soglia Proteina BRAF Punto nel tempo (episodio)
zh-CN Chinese (China) 丝氨酸-苏氨酸蛋白激酶 B-raf:存在情况或阈值:时间点:癌标本:序数型:免疫染色法
Synonyms: B 型 Beta-羟丁氨酸;Thr;β-羟丁氨酸;羟基丁氨酸 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 Ser STK B-raf 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 染法 染色方法 染色法 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 着色 着色方法 着色法 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81705-6