PTEN gene [Presence] in Cancer specimen by FISH
LP61787-5 PTEN gene
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as phosphate and tensin homolog or PTEN protein, is encoded by the PTEN gene on chromosome10q23.31. PTEN protein has multiple functions, including protein phosphatase and lipid phosphatase activity. The lipid phosphatase function is critical for its role as a tumor suppressor and modulating cell cycle progression and cell survival. It also plays a role in correct neuron positioning, dendritic development and synapse formation, and may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. Mutations in the PTEN gene are associated with multiple disorders, including PTEN hamartoma tumor syndromes, which include Cowden syndrome and Lhermitte-Duclos disease, squamous cell carcinoma of the head and neck, endometrial carcinoma, prostate cancer, and VACTERL with hydrocephalus. [UniProt: P60484] Loss of the PTEN gene can be determined by various techniques, including FISH, and loss of the PTEN protein can be detected by immunohistochemistry techniques. Source: Regenstrief LOINC, UniProt: P60484
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH
- PTEN gene
- Cancer specimen
- Short Name
- PTEN gene Ca spec Ql FISH
- Display Name
- PTEN gene FISH Ql (Cancer specimen)
- Consumer Name Alpha
- PTEN gene, Cancer specimen
Example Answer List: LL2038-9Source: Quest Diagnostics Inc.
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
|IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)||LA11884-6|
- First Released
- Version 2.56
- Last Updated
- Version 2.61
- Change Reason
- Updated System from "Tiss" to "Cancer.XXX" because PTEN gene testing is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
- Order vs. Observation
Member of these Panels
|LOINC||Long Common Name|
|85905-8||Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols|
|zh-CN||Chinese (China)||PTEN 基因:
|es-ES||Spanish (Spain)||Gen PTEN:
|it-IT||Italian (Italy)||PTEN, gene:
|fr-FR||French (France)||PTEN gène:
|es-MX||Spanish (Mexico)||Gen PTEN:
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright