Version 2.74

Part Descriptions

LP61787-5   PTEN gene
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as phosphate and tensin homolog or PTEN protein, is encoded by the PTEN gene on chromosome10q23.31. PTEN protein has multiple functions, including protein phosphatase and lipid phosphatase activity. The lipid phosphatase function is critical for its role as a tumor suppressor and modulating cell cycle progression and cell survival. It also plays a role in correct neuron positioning, dendritic development and synapse formation, and may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. Mutations in the PTEN gene are associated with multiple disorders, including PTEN hamartoma tumor syndromes, which include Cowden syndrome and Lhermitte-Duclos disease, squamous cell carcinoma of the head and neck, endometrial carcinoma, prostate cancer, and VACTERL with hydrocephalus. [UniProt: P60484] Loss of the PTEN gene can be determined by various techniques, including FISH, and loss of the PTEN protein can be detected by immunohistochemistry techniques. Source: Regenstrief LOINC, UniProt: P60484

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, FISH

Fully-Specified Name

PTEN gene
Cancer specimen

Additional Names

Short Name
PTEN gene Ca spec Ql FISH
Display Name
PTEN gene FISH Ql (Cancer specimen)
Consumer Name Alpha
PTEN gene, Cancer specimen

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
PositiveCopyright ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright ID:260385009 Negative (qualifier value) LA6577-6
IndeterminateCopyright ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

First Released
Version 2.56
Last Updated
Version 2.61
Change Reason
Updated System from "Tiss" to "Cancer.XXX" because PTEN gene testing is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation

Member of these Panels

LOINC Long Common Name
85905-8 Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols

Language Variants

Tag Language Translation
zh-CN Chinese (China) PTEN 基因:存在情况或阈值:时间点:癌标本:序数型:FISH
Synonyms: Bannayan-Zonana 综合征(Bannayan-Zonana syndrome,BZS);BZS;Human mutated in multiple advanced cancers protein (MMAC1) mRNA, complete cds;MGC11227;MHAM;MMAC1;Mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;PTEN1;TEP1;人类突变于多种进行性癌蛋白 (MMAC1) Fluorescent in situ hybridization;荧光原位杂交 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子病理学.杂项;分子病理学试验.杂项;分子病理学试验类.其他 分子病理学;分子病理学试验 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 杂项;杂项类;杂项试验 样品 样本 癌 癌(癌症、癌变)标本(样本、样品、试样) 试样 遗传基因;遗传因子;吉恩;生物基因
es-ES Spanish (Spain) Gen PTEN:PrThr:Punto temporal:Muestra de cancer:Ord:Hibridación in situ fluoresente (FISH)
it-IT Italian (Italy) PTEN, gene:PrThr:Pt:Campione tumore:Ord:FISH
Synonyms: Campione di tumore Gene PTEN Ibridazione in situ fluorescente (FISH) Miscellanea Miscellanea geni Neoplasia maligna Patologia molecolare Presenza o Soglia Punto nel tempo (episodio)
fr-FR French (France) PTEN gène:Présence/Seuil:Ponctuel:Tissu cancereux:Qualitatif:FISH
es-MX Spanish (Mexico) Gen PTEN:Presencia o umbral:Punto temporal:Espécimen de cáncer:Ordinal:Hibridación fluorescente in situ (FISH)

LOINC Terminology Service (API) using HL7® FHIR®

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