81742-9

Th-To Ab [Units/volume] in Serum by Line blot

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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Descriptions

LP157204-1 Th-To Ab
Patient's with Th/To autoantibodies immunoprecipitate two small RNAs, known as 7-2 RNA (also RNAase MRP or Th) and 8-2 RNA (also RNAase P, H1 and To). 7-2 RNA is involved in processing of pre-rRNA and 8-2 RNA is involved in maturation of tRNA. Anti-Th/To is frequently detected in the sera of patients with scleroderma and their presence may be associated with a less favorable prognosis. Source: Regenstrief LOINC, PMID: 20175839

LP157267-8 Th-To
Th/To are small nuclear ribonucleoproteins located in the nucleoli of cells. Anti-Th/To antibodies, a type of antinuclear antibodies (ANA), are present in a small subset (2-5%) of patients with with limited cutaneous systemic sclerosis (lSSc). But they present a higher risk for severe organ involvement and therefore a worse prognosis. Severe pulmonary fibrosis followed by pulmonary hypertension have been reported. Source: Regenstrief LOINC, PMID: 20175839

LOINC Names Get Info

Fully-Specified Name: Th-To Ab:ACnc:Pt:Ser:Qn:Line blot
Long Common Name: Th-To Ab [Units/volume] in Serum by Line blot
Short Name: Th-To Ab Ser Line blot-aCnc
Display Name: Th-To Ab Line blot Qn (S)
Consumer Name Alpha Get Info: Th-To antibody, Blood

Part Model Get Info

Component
Th-To Ab
LP157204-1
- Analyte
  Th-To Ab
  LP157204-1
  - Component Numerator
    Th-To Ab
    LP157204-1
    - Component Numerator Core
      Th-To
      LP157267-8
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
Line blot
LP266806-1

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.73 (MIN)
Change Reason: This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation: Both
Common Test Rank Get Info: 16073

Member of these Panels

LOINC	Long Common Name
88702-6	Systemic sclerosis Ab panel - Serum by Immunoassay

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Th-To Ab:Arbitrární koncentrace:Časový bod:Sérum:Kvantitativní:Line blot
el-GR	Greek (Greece)	Th-To Αντίσωμα:ACnc:Pt:Ορός:Qn:Γραμμή κηλίδωσης Synonyms: ACnc Pt Qn SERO Th-To Αντίσωμα Γραμμή κηλίδωσης Ορός
es-ES	Spanish (Spain)	Th-To Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Th-To Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-FR	French (France)	Th-To Ac:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT	Italian (Italy)	Th-To Ab:ACnc:Pt:Siero:Qn:Line blot Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	Th-To As:eenheid/volume:moment:serum:kwantitatief:lijnblot Synonyms: antistof; antilichaam
zh-CN	Chinese (China)	Th-To 抗体:任意型浓度:时间点:血清:定量型:线点印迹法 Synonyms: Ab;自身抗体 Th/To;核内小核糖核蛋白;systemic sclerosis;系统性硬化病;硬皮病;SSc;PM/Scl overlap syndrome;系统性硬化病与多发性肌炎重叠综合征任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间线点杂交技术;线点杂交法;线条状印迹法血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类钍

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.