Th-To Ab [Presence] in Serum by Line blot
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
LP157204-1 Th-To Ab
Patient's with Th/To autoantibodies immunoprecipitate two small RNAs, known as 7-2 RNA (also RNAase MRP or Th) and 8-2 RNA (also RNAase P, H1 and To). 7-2 RNA is involved in processing of pre-rRNA and 8-2 RNA is involved in maturation of tRNA. Anti-Th/To is frequently detected in the sera of patients with scleroderma and their presence may be associated with a less favorable prognosis. Source: Regenstrief LOINC, PMID: 20175839
Th/To are small nuclear ribonucleoproteins located in the nucleoli of cells. Anti-Th/To antibodies, a type of antinuclear antibodies (ANA), are present in a small subset (2-5%) of patients with with limited cutaneous systemic sclerosis (lSSc). But they present a higher risk for severe organ involvement and therefore a worse prognosis. Severe pulmonary fibrosis followed by pulmonary hypertension have been reported. Source: Regenstrief LOINC, PMID: 20175839
- Th-To Ab
- Line blot
- Short Name
- Th-To Ab Ser Ql Line blot
- Display Name
- Th-To Ab Line blot Ql (S)
- Consumer Name Alpha Get Info
- Th-To antibody, Blood
Example Answer List: LL360-9Source: Regenstrief Institute
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
- First Released
- Version 2.56
- Last Updated
- Version 2.64
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
Language Variants Get Info
|de-AT||German (Austria)||Synonyms: Th/To AK ql.|
|es-ES||Spanish (Spain)||Th-To Anticuerpos:
|es-MX||Spanish (Mexico)||Th-To Ab:
|fr-FR||French (France)||Th-To anticorps:
|it-IT||Italian (Italy)||Th-To Ab:
Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
|nl-NL||Dutch (Netherlands)||Th-To As:
|zh-CN||Chinese (China)||Th-To 抗体:
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Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright