81768-4

U1 small nuclear ribonucleoprotein 70kD IgG Ab [Units/volume] in Serum by Immunoassay

Active

Part Description

LP69897-4 U1 small nuclear ribonucleoprotein 70kD
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1-70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. PMID: 24158973 In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. PMID: 20015915 Source: Regenstrief LOINC, PMID: 24158973

LOINC Names Get Info

Fully-Specified Name: U1 small nuclear ribonucleoprotein 70kD Ab.IgG:ACnc:Pt:Ser:Qn:IA
Long Common Name: U1 small nuclear ribonucleoprotein 70kD IgG Ab [Units/volume] in Serum by Immunoassay
Short Name: U1 snRNP70 IgG Ser IA-aCnc
Display Name: U1 small nuclear ribonucleoprotein 70kD IgG IA Qn (S)
Consumer Name Alpha Get Info: U1 small nuclear ribonucleoprotein 70kD IgG antibody, Blood

Part Model Get Info

Component
U1 small nuclear ribonucleoprotein 70kD Ab.IgG
LP213587-1
- Analyte
  U1 small nuclear ribonucleoprotein 70kD Ab.IgG
  LP213587-1
  - Component Numerator
    U1 small nuclear ribonucleoprotein 70kD Ab.IgG
    LP213587-1
    - Component Numerator Core
      U1 small nuclear ribonucleoprotein 70kD
      LP69897-4
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.56 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	U1 malý jaderný ribonukleoprotein 70kD IgG:Arbitrární koncentrace:Časový bod:Sérum:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Μικρή πυρηνική ριβονουκλεοπρωτεΐνη 70kD Αντισώματα IgG:ACnc:Pt:Ορός:Qn:IA Synonyms: ACnc CHEM IA Pt Qn Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Μικρή πυρηνική ριβονουκλεοπρωτεΐνη 70kD Μικρή πυρηνική ριβονουκλεοπρωτεΐνη U1 Ορός Πυρηνικό
es-ES	Spanish (Spain)	U1 ribonucleoproteína nuclear pqueña de 70kD IgG:Concentración arbitraria:Punto temporal:Suero:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	U1 ribonucleoproteína nuclear sub 70 kD IgG:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Inmunoensayo
fr-CA	French (Canada)	Petite particule nucléaire ribonucléoprotéique U1 70kD, IgG:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA
fr-FR	French (France)	RNP 70kD Ac IgG:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
fr-BE	French (Belgium)	Petite particule nucléaire ribonucléoprotéique U1 70kD Anticorps. IgG:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:IA Synonyms: Anticorps
it-IT	Italian (Italy)	U1, piccola ribonucleoproteina nucleare 70kD Ab.IgG:ACnc:Pt:Siero:Qn:IA Synonyms: anticorpi IgG anticorpo Chimica Concentrazione Arbitraria Immunoassay Piccola ribonucleoproteina nucleare U1 Piccola ribonucleoproteina nucleare U1 70kD Punto nel tempo (episodio) Siero
nl-NL	Dutch (Netherlands)	u1 small nucleair ribonucleoproteïne 70kD As.IgG:eenheid/volume:moment:serum:kwantitatief:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	U1 mała jądrowa nukleoproteina 70kDa Ab.IgG:stężenie w jednostkach umownych:punkt w czasie:surowica:ilościowy:metoda immunologiczna Synonyms: IgG Mała rybonukleoproteina jądrowa U1 przeciwciała IgG Przeciwciała IgG do małych jądrowych rybonukleoprotein U1 70 kD U1-snRNP 70 kDa
ru-RU	Russian (Russian Federation)	U1 малый ядерный рибонуклеопротеин 70кД Ат.IgG:ПроизвКонц:ТчкВрм:Сыв:Колич:IA Synonyms: Антитело Количественный Произвольная концентрация Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	U1 kçk nükleer ribonükleoprotein 70kD Ab.IgG:SçKons:Zmlı:Ser:Kant:İA Synonyms: Ak Ak.IgG Çekirdek İmmünölçüm, immünoassay
zh-CN	Chinese (China)	U1 小细胞核核糖核蛋白 70kD 抗体.IgG:任意型浓度:时间点:血清:定量型:免疫测定法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 RNP snRNP U1 RNP 70kD;U1 snRNP 70kD;U1 小细胞核核糖核蛋白 70kD;U1 small nuclear ribonucleoprotein 70kD;U1RNP 70kD U1 RNP;U1 snRNP;U1 小细胞核核糖核蛋白;U1 small nuclear ribonucleoprotein;U1RNP 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验免疫球蛋白 G 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺小分子核糖核蛋白体小分子细胞核核糖核蛋白小核核糖核蛋白（Small nuclear ribonucleoprotein，snRNP）时刻;随机;随意;瞬间核;胞核核内小核糖核蛋白核微小核糖核蛋白核心抗体IgG 核心抗原抗体.IgG 核心抗原抗体IgG 核抗体.IgG 核抗体IgG 核抗原抗体.IgG 核抗原抗体IgG 核糖核蛋白（Ribonucleoprotein，Ribonuclear protein，RNP）核蛋白

Example Units

Unit	Source
[IU]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.