Version 2.78

Term Description

This assay detects the presence of nucleic acid sequences from the Cytomegalovirus DNA in cerebrospinal fluid (CSF) using PCR and non-probe based detection methods, such as melt curve analysis. This term was created for, but is not limited in use to, BioFire's FilmArray Meningitis/Encephalitis Panel, which is intended for the detection and identification of nucleic acids from multiple bacteria, viruses, and yeast directly from CSF obtained via lumbar puncture from individuals with signs and/or symptoms of meningitis and/or encephalitis.
Source: Regenstrief LOINC

Part Description

LP14255-1   Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Cytomegalovirus DNA
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
Non-probe.amp.tar

Additional Names

Short Name
CMV DNA CSF Ql NAA+non-probe
Display Name
CMV DNA NAA+non-probe Ql (CSF)
Consumer Name Alpha Get Info
Cytomegalovirus (CMV), Spinal fluid

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
4251

Member of these Panels

LOINC Long Common Name
82180-1 Meningitis+Encephalitis pathogens panel - Cerebral spinal fluid by NAA with non-probe detection

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Cytomegalie-Virus DNA:Nachweis oder Schwellenwert:Zeitpunkt:Liquor:Ordinal:Zielfragmentamplifikation mit Detektion ohne Sonde
Synonyms: CMV; Zerebrospinalflüssigkeit
es-ES Spanish (Spain) Citomegalovirus ADN:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:Amplificación del objetivo no basado en sonda
es-MX Spanish (Mexico) ADN de citomegalovirus:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
fr-CA French (Canada) Cytomégalovirus, ADN:Présence-Seuil:Temps ponctuel:LCR:Ordinal:Non-sonde.amplification de cible
fr-FR French (France) Cytomégalovirus ADN:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Non-PCR amplification de cible
it-IT Italian (Italy) Citomegalovirus DNA:PrThr:Pt:LCS:Ord:Non-sonda.amp.tar
Synonyms: Amplificazione target non basata su sonda Liquido cerebrospinale Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
uk-UA Ukrainian (Ukraine) Цитомегаловірус ДНК:Наявність або Поріг:МоментЧасу:Спинномозкова рідина:Порядково:Детекція без зонда.цільова аміпліфікація НК
Synonyms: 3 Self-Sustaining Sequence Replication; 3SR SR; Amplif; Amplification; Amplified; Cerebral spinal fluid; Cerebrospinal Fl; CMV; Cytomegalo virus; Cytomgal; Deoxyribonucleic acid; DNA NUCLEIC ACID PROBE; DNA probe; HHV-5; Human Herpesvirus-5; ID; Infectious Disease; InfectiousDisease; LAT; LCR; Ligase chain reaction; Ligation-activated transcription; Microbiology; NAA+non-probe; NAA+probe; NAAT; NASBA; Neuro; Neurology; Nucleic acid sequence based analysis; Ordinal; PCR; Point in time; Polymerase chain reaction; PR; Probe amp; Probe with ampification; Probe with target amplification; QBR; QL; Qual; Qualitative; Random; Screen; SDA; Spinal Fl; Spinal Fld; Spinal Flu; Spinal Fluid; Strand Displacement Amplification; TMA; Transcription mediated amplification
zh-CN Chinese (China) 巨细胞病毒 DNA:存在情况或阈值:时间点:脑脊液:序数型:非探针法.基因扩增.靶向
Synonyms: CMV DNA CMV;涎腺病毒;细胞巨化病毒;细胞肥大病毒 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 借助靶向扩增的非探针方法;借助靶向扩增的非探针法;非探针法.扩增.靶向 去氧核糖核酸;脱氧核糖核酸 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 脱氧核糖核酸探针

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82189-2