Version 2.77

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP220363-8   3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase (HMG-CoA reductase or HMGCR) is an enzyme in the cholesterol-synthesis pathway and is the target of HMG-CoA reductase inhibitors, also known as statins. Autoantibodies to HMGCR may be a marker of necrotizing autoimmune myopathy (NAM), which is characterized by muscle fiber necrosis with little or no inflammation and responsiveness to immunosuppressive treatment. Anti-HMGCR positive cases of NAM usually have limited extramuscular involvement, slow onset of muscle disease, and can occur in both adults and children. Due to the insidious onset, pediatric cases of NAM may be initially confused with muscular dystrophy. The anti-HMGCR antibody titer may correlate with muscle strength and creatine kinase level. Some cases of NAM have been diagnosed in patients previously exposed to statins, and in some of these cases, stopping the statin drug was the only intervention necessary for the resolution of disease. However, exposure to statins is not required to diagnose cases of NAM, and first-line treatment typically includes corticosteroids or other immunosuppressive drugs such as methotrexate. PMID: 24797170 Source: Regenstrief LOINC, PMID: 24797170

Fully-Specified Name

Component
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
Line blot

Additional Names

Short Name
HMGCR Ab Ser Line blot-aCnc
Display Name
3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab Line blot Qn (S)
Consumer Name Alpha Get Info
3-Hydroxy-3-Methylglutaryl-coenzyme A Reductase antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.68
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG51037-6 3-Hydroxy-3-Methylglutaryl-coenzyme A reductase Ab|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) 3-Hidroxy-3-metilglutaril-CoA reductasa Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
es-MX Spanish (Mexico) 3-hidroxi-3-metilglutaril-coenzima A reductasa Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-FR French (France) 3-hydroxy-3-méthylglutaryl-coenzyme A réductase anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT Italian (Italy) 3-idrossi-3-metilglutaril-coenzima A reduttasi Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) 3-hydroxy-3-methylglutaryl-CoA-reductase As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 3-羟基-3-甲基戊二酰-辅酶 A 还原酶 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: 3-羟基-3-甲基戊二酰基-辅酶 A 还原酶;3-羟基-3-甲基戊二酰基辅酶 A 还原酶;3-羟基-3-甲基戊二酰辅酶 A 还原酶;3-羟基-3-甲基戊二酰-CoA 还原酶;3-羟基-3-甲基戊二酰基-CoA 还原酶;3-羟基-3-甲基戊二酰基 CoA 还原酶;3-羟基-3-甲基戊二酰 CoA 还原酶 Ⅲ A 型 Ab;自身抗体 Hydroxy III OH 三 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 叁 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 线点杂交技术;线点杂交法;线条状印迹法 羟 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82388-0