Version 2.77

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP71684-2   Centromere protein B Ab
Major centromere autoantigen B, also known as centromere protein B or CENP-B, is encoded by the CENPB gene located on chromosome 20p13. CENP-B interacts with chromosomal centromeric heterochromatin and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. [UniProt: P07199] CENP-B plays a direct role in stablizing CENP-C, which is a kinetochore assembly nucleator, and recruiting CENP-A, which marks and maintains centromere position. Chromosomes that have centromeres without bound CENP-B, including the human Y chromosome, are more likely to missegregate at much higher rates than chromosomes with CENP-B containing centromeres. PMID: 25942623 Autoantibodies to both CENP-A and CENP-B are markers for scleroderma and other rheumatic diseases. PMID: 17210244 Source: Regenstrief LOINC, UniProt: P07199

Fully-Specified Name

Component
Centromere protein B Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
Line blot

Additional Names

Short Name
Centromere B Ab Ser Line blot-aCnc
Display Name
Centromere protein B Ab Line blot Qn (S)
Consumer Name Alpha Get Info
Centromere Protein B antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.68
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
88702-6 Systemic sclerosis panel - Serum by Immunoassay

Member of these Groups Get Info

LOINC Group Group Name
LG21821-0 Centromere protein B Ab|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Proteína B del centrómero Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Centrómero de proteína B Ab:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-CA French (Canada) Centromère protéine B , Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR French (France) Centromère protéine B anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT Italian (Italy) Centromero, proteina B Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria Proteina B del centromero Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) centromeereiwit B As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 着丝点蛋白 B 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: Ab;自身抗体 B 型 B型抗体 CRST 综合征;着丝粒;动粒 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 着丝粒蛋白 B;动粒蛋白 B 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目(非微生物学);血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验(非微生物学);血清学试验类 (非微生物学);血清类

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82391-4