Version 2.78

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP14394-8   Ganglioside GD1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

Fully-Specified Name

Component
Ganglioside GD1b Ab.IgG+IgM
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
GD1b Gangl IgG+IgM Ser Ql Line blot
Display Name
Ganglioside GD1b IgG+IgM Line blot Ql (S)
Consumer Name Alpha Get Info
Ganglioside GD1b IgG+IgM, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
82455-7 Ganglioside Ab panel - Serum

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gangliosido GD1b IgG+IgM:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX Spanish (Mexico) Gangliósido GD1b Ab.IgG + IgM:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CA French (Canada) Ganglioside GD1b, IgG+IgM:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FR French (France) Ganglioside GD1b anticorps IgG+IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-IT Italian (Italy) Ganglioside GD1b Ab.IgG+IgM:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpi IgG anticorpi IgG e IgM Anticorpi IgG+IgM anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) ganglioside GD1b As.IgG + IgM:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 神经节苷脂 GD1b 抗体.IgG+IgM:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab.IgG+IgM;IgG+IgM;抗体 IgG+抗体 IgM Ab;自身抗体 GD1b;神经节糖苷 GD1b 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 免疫球蛋白 M 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗体.IgG & IgM;抗体.IgG+IgM 时刻;随机;随意;瞬间 神经节糖苷 神经节苷脂 GD1b Ab 神经节苷脂 GD1b Ab.IgG 神经节苷脂 GD1b IgG 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
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